Neural stem cell dynamics: the development of brain tumours.
Current Opinion in Cell Biology
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Hakes, A., & Brand, A. (2019). Neural stem cell dynamics: the development of brain tumours.. Current Opinion in Cell Biology, 60 131-138. https://doi.org/10.1016/j.ceb.2019.06.001
Determining the premalignant lesions that develop into malignant tumours remains a daunting task. Brain tumours are frequently characterised by a block in differentiation, implying that normal developmental pathways become hijacked during tumourigenesis. However, the heterogeneity of stem cells and their progenitors in the brain suggests there are many potential routes to tumour initiation. Studies in Drosophila melanogaster have enhanced our understanding of the tumourigenic potential of distinct cell types in the brain. Here we review recent studies that have improved our knowledge of neural stem cell behaviour during development and in brain tumour models.
This work was funded by: Wellcome Trust Senior Investigator Award (103792 to A.H.B.), The Royal Society Darwin Trust Research Professorship (to A.H.B.) and Wellcome Trust PhD Studentship (102454 to A.E.H.). A.H.B acknowledges core funding to The Gurdon Institute from the Wellcome Trust (092096) and CRUK (C6946/A14492).
WELLCOME TRUST (103792/Z/14/Z)
Wellcome Trust (092096/Z/10/Z)
Wellcome Trust (102454/Z/13/Z)
Cancer Research UK (A14492)
Royal Society (RP150061)
External DOI: https://doi.org/10.1016/j.ceb.2019.06.001
This record's URL: https://www.repository.cam.ac.uk/handle/1810/299822
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