p53-Mediated Tumor Suppression: DNA-Damage Response and Alternative Mechanisms.
Published version
Peer-reviewed
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Repository DOI
Change log
Authors
Pitolli, Consuelo
Wang, Ying
Candi, Eleonora
Shi, Yufang
Melino, Gerry https://orcid.org/0000-0001-9428-5972
Abstract
The tumor suppressor p53 regulates different cellular pathways involved in cell survival, DNA repair, apoptosis, and senescence. However, according to an increasing number of studies, the p53-mediated canonical DNA damage response is dispensable for tumor suppression. p53 is involved in mechanisms regulating many other cellular processes, including metabolism, autophagy, and cell migration and invasion, and these pathways might crucially contribute to its tumor suppressor function. In this review we summarize the canonical and non-canonical functions of p53 in an attempt to provide an overview of the potentially crucial aspects related to its tumor suppressor activity.
Description
Keywords
cancer, cell death, epigenetics, metabolism
Journal Title
Cancers (Basel)
Conference Name
Journal ISSN
2072-6694
2072-6694
2072-6694
Volume Title
11
Publisher
MDPI AG
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Sponsorship
This work is funded by the Medical Research Council and partially supported by AIRC (IG22206 to EC) and Ministry of Health (IDI-IRCCS)-MAECI (CN18GR09 to EC).