Show simple item record

dc.contributor.authorO'Brien, Katieen
dc.contributor.authorSimonson, TSen
dc.contributor.authorMurray, Andrewen
dc.date.accessioned2019-12-14T00:30:36Z
dc.date.available2019-12-14T00:30:36Z
dc.date.issued2020-04-01en
dc.identifier.issn2451-9650
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/299896
dc.description.abstractAt high-altitude, hypobaric hypoxia is a significant stress for humans and other animals, challenging oxygen homeostasis and therefore tissue metabolism. Genetic signals of physiological adaptation have been identified in human populations and non-human species with long-term residence at high-altitude. In Tibetans, some genetic signals are linked to altered metabolic function, e.g. variants in EPAS1 are associated with increased glycolysis, whilst variants in PPARA are associated with a decreased capacity for fatty acid oxidation. A number of other genetic signals that may impact on metabolism have been identified in Tibetans and other populations, although the downstream consequences are not well-defined. Use of high-throughput technologies to comprehensively profile metabolic phenotype could advance understanding of the evolutionary processes conferring hypoxia tolerance at high-altitude.
dc.rightsAll rights reserved
dc.rights.uri
dc.titleMetabolic adaptation to high altitudeen
dc.typeArticle
prism.endingPage41
prism.publicationDate2020en
prism.publicationNameCurrent Opinion in Endocrine and Metabolic Researchen
prism.startingPage33
prism.volume11en
dc.identifier.doi10.17863/CAM.46966
dcterms.dateAccepted2019-12-11en
rioxxterms.versionofrecord10.1016/j.coemr.2019.12.002en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2020-04-01en
dc.contributor.orcidO'Brien, Katie [0000-0002-0189-1971]
dc.contributor.orcidSimonson, TS [0000-0003-4062-2587]
dc.contributor.orcidMurray, Andrew [0000-0002-0929-9315]
dc.identifier.eissn2451-9650
rioxxterms.typeJournal Article/Reviewen
cam.orpheus.counter48*
rioxxterms.freetoread.startdate2022-12-13


Files in this item

Thumbnail
Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record