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dc.contributor.authorLittle, Bethanyen
dc.contributor.authorAlshabrawy, Ossamaen
dc.contributor.authorStow, Danielen
dc.contributor.authorFerrier, I Nicolen
dc.contributor.authorMcNaney, Roisinen
dc.contributor.authorJackson, Daniel Gen
dc.contributor.authorLadha, Karimen
dc.contributor.authorLadha, Cassimen
dc.contributor.authorPloetz, Thomasen
dc.contributor.authorBacardit, Jaumeen
dc.contributor.authorOlivier, Patricken
dc.contributor.authorGallagher, Peteren
dc.contributor.authorO'Brien, Johnen
dc.date.accessioned2019-12-19T00:30:26Z
dc.date.available2019-12-19T00:30:26Z
dc.date.issued2020-01-16en
dc.identifier.issn0033-2917
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/300078
dc.description.abstractBackground: Late-life depression (LLD) is associated with poor social functioning. However, previous research uses bias-prone self-report scales to measure social functioning and a more objective measure is lacking. We tested a novel wearable device to measure speech that participants encounter as an indicator of social interaction. Methods: 29 participants with LLD and 29 age-matched controls wore a wrist-worn device continuously for seven days, which recorded their acoustic environment. Acoustic data were automatically analysed using deep learning models that had been developed and validated on an independent speech dataset. Total speech activity and the proportion of speech produced by the device wearer were both detected whilst maintaining participants’ privacy. Participants underwent a neuropsychological test battery and clinical and self-report scales to measure severity of depression, general and social functioning. Results: Compared to controls, participants with LLD showed poorer self-reported social and general functioning. Total speech activity was much lower for participants with LLD than controls, with no overlap between groups. The proportion of speech produced by the participants was smaller for LLD than controls. In LLD, both speech measures correlated with attention and psychomotor speed performance but not with depression severity or self-reported social functioning. Conclusions: Using this device, LLD was associated with lower levels of speech than controls and speech activity was related to psychomotor retardation. We have demonstrated that speech activity measured by wearable technology differentiated LLD from controls with high precision and, in this study, provided an objective measure of an aspect of real-world social functioning in LLD.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherCambridge University Press
dc.rightsAll rights reserved
dc.rights.uri
dc.titleDeep learning-based automated speech detection as a marker of social functioning in late-life depression.en
dc.typeArticle
prism.endingPage10
prism.publicationDate2020en
prism.publicationNamePsychological medicineen
prism.startingPage1
dc.identifier.doi10.17863/CAM.47152
dcterms.dateAccepted2019-12-13en
rioxxterms.versionofrecord10.1017/s0033291719003994en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2020-01-16en
dc.contributor.orcidLittle, Bethany [0000-0003-1300-0176]
dc.contributor.orcidMcNaney, Roisin [0000-0003-3761-296X]
dc.contributor.orcidBacardit, Jaume [0000-0002-2692-7205]
dc.contributor.orcidO'Brien, John [0000-0002-0837-5080]
dc.identifier.eissn1469-8978
rioxxterms.typeJournal Article/Reviewen
cam.orpheus.successTue Mar 31 10:38:33 BST 2020 - Embargo updated*
cam.orpheus.counter2*
rioxxterms.freetoread.startdate2020-07-16


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