Challenges in measuring and understanding biological noise.
Nature Reviews Genetics
MetadataShow full item record
Eling, N., Morgan, M., & Marioni, J. (2019). Challenges in measuring and understanding biological noise.. Nature Reviews Genetics, 20 (9), 536-548. https://doi.org/10.1038/s41576-019-0130-6
Biochemical reactions are intrinsically stochastic, leading to variation in the production of mRNAs and proteins within cells. In the scientific literature, this source of variation is typically referred to as 'noise'. The observed variability in molecular phenotypes arises from a combination of processes that amplify and attenuate noise. Our ability to quantify cell-to-cell variability in numerous biological contexts has been revolutionized by recent advances in single-cell technology, from imaging approaches through to 'omics' strategies. However, defining, accurately measuring and disentangling the stochastic and deterministic components of cell-to-cell variability is challenging. In this Review, we discuss the sources, impact and function of molecular phenotypic variability and highlight future directions to understand its role.
N.E. was supported by the European Molecular Biology Laboratory (EMBL) International PhD Programme. M.D.M. was supported by Wellcome Trust grant 105045/Z/14/Z to J.C.M. J.C.M. was supported by core funding from EMBL and Cancer Research UK (award number 17197).
Cancer Research UK (C14303/A17197)
External DOI: https://doi.org/10.1038/s41576-019-0130-6
This record's URL: https://www.repository.cam.ac.uk/handle/1810/300153
All rights reserved