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dc.contributor.authorEling, Nilsen
dc.contributor.authorMorgan, Michaelen
dc.contributor.authorMarioni, Johnen
dc.date.accessioned2019-12-20T00:30:30Z
dc.date.available2019-12-20T00:30:30Z
dc.date.issued2019-09en
dc.identifier.issn1471-0056
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/300153
dc.description.abstractBiochemical reactions are intrinsically stochastic, leading to variation in the production of mRNAs and proteins within cells. In the scientific literature, this source of variation is typically referred to as 'noise'. The observed variability in molecular phenotypes arises from a combination of processes that amplify and attenuate noise. Our ability to quantify cell-to-cell variability in numerous biological contexts has been revolutionized by recent advances in single-cell technology, from imaging approaches through to 'omics' strategies. However, defining, accurately measuring and disentangling the stochastic and deterministic components of cell-to-cell variability is challenging. In this Review, we discuss the sources, impact and function of molecular phenotypic variability and highlight future directions to understand its role.
dc.description.sponsorshipN.E. was supported by the European Molecular Biology Laboratory (EMBL) International PhD Programme. M.D.M. was supported by Wellcome Trust grant 105045/Z/14/Z to J.C.M. J.C.M. was supported by core funding from EMBL and Cancer Research UK (award number 17197).
dc.languageengen
dc.publisherSpringer Nature
dc.rightsAll rights reserved
dc.rights.uri
dc.titleChallenges in measuring and understanding biological noise.en
dc.typeArticle
prism.endingPage548
prism.issueIdentifier9en
prism.publicationDate2019en
prism.publicationNameNature Reviews Geneticsen
prism.startingPage536
prism.volume20en
dc.identifier.doi10.17863/CAM.47224
rioxxterms.versionofrecord10.1038/s41576-019-0130-6en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-09en
dc.contributor.orcidMorgan, Michael [0000-0003-0757-0711]
dc.contributor.orcidMarioni, John [0000-0001-9092-0852]
dc.identifier.eissn1471-0064
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idCancer Research UK (C14303/A17197)
cam.issuedOnline2019-05-21en
cam.orpheus.successThu Jan 30 10:34:53 GMT 2020 - Embargo updated*
rioxxterms.freetoread.startdate2019-11-01


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