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dc.contributor.authorVarankar, Sagaren
dc.contributor.authorMore, Madhurien
dc.contributor.authorAbraham, Ancyen
dc.contributor.authorPansare, Kshamaen
dc.contributor.authorKumar, Brijeshen
dc.contributor.authorNarayanan, Nivedhitha Jen
dc.contributor.authorJolly, Mohit Kumaren
dc.contributor.authorMali, Avinash Men
dc.contributor.authorBapat, Sharmila Aen
dc.date.accessioned2019-12-20T00:31:10Z
dc.date.available2019-12-20T00:31:10Z
dc.identifier.issn0143-3334
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/300179
dc.description.abstractCellular plasticity and transitional phenotypes add to complexities of cancer metastasis that can be initiated by single cell epithelial to mesenchymal transition (EMT) or cooperative cell migration (CCM). Our study identifies novel regulatory cross-talks between Tcf21 and Slug in mediating phenotypic and migration plasticity in high-grade serous ovarian adenocarcinoma (HGSC). Differential expression and sub-cellular localization associate Tcf21, Slug with epithelial, mesenchymal phenotypes respectively; however gene manipulation approaches identify their association with additional intermediate phenotypic states, implying the existence of a multi-step epithelial-mesenchymal transition program. Live imaging further associated distinct migratory modalities with the Tcf21/Slug status of cell systems and discerned proliferative/passive CCM, active CCM and EMT modes of migration. Tcf21-Slug balance identified across a phenotypic spectrum in HGSC cell lines, associated with micro-environment induced transitions and the emergence of an epithelial phenotype following drug exposure. Phenotypic transitions and associated functionalities following drug exposure were affirmed to ensue from occupancy of Slug promoter E-box sequences by Tcf21. Our study effectively provides a framework for understanding the relevance of ovarian cancer plasticity as a function of two transcription factors.
dc.languageengen
dc.publisherOxford University Press
dc.rightsAll rights reserved
dc.rights.uri
dc.subjectPlasticityen
dc.subjectSlugen
dc.subjectTcf21en
dc.subjectmigratory modalitiesen
dc.subjectsub-cellular localizationen
dc.titleFunctional balance between Tcf21-Slug defines cellular plasticity and migratory modalities in high grade serous ovarian cancer cell lines.en
dc.typeArticle
prism.publicationNameCarcinogenesisen
dc.identifier.doi10.17863/CAM.47250
dcterms.dateAccepted2019-06-21en
rioxxterms.versionofrecord10.1093/carcin/bgz119en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-06-21en
dc.contributor.orcidVarankar, Sagar [0000-0002-2923-8616]
dc.identifier.eissn1460-2180
rioxxterms.typeJournal Article/Reviewen
cam.issuedOnline2019-06-25en
cam.orpheus.successThu Jan 30 10:34:48 GMT 2020 - Embargo updated*
rioxxterms.freetoread.startdate2020-06-25


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