Repository logo
 

Comment on "Protein assemblies ejected directly from native membranes yield complexes for mass spectrometry".

Accepted version
Peer-reviewed

Type

Article

Change log

Abstract

Chorev et al (Reports, 16 November 2018, p. 829) describe mass spectrometry on mitochondrial membrane proteins ionized directly from their native environment. However, the assignments made to measured masses are incorrect or inconclusive and lack experimental validation. The proteins are not in their "native" condition: They have been stripped of tightly bound lipids, and the complexes are fragmented or in physiologically irrelevant oligomeric states.

Description

Keywords

Lipids, Mass Spectrometry, Membrane Proteins

Journal Title

Science

Conference Name

Journal ISSN

0036-8075
1095-9203

Volume Title

366

Publisher

American Association for the Advancement of Science (AAAS)

Rights

All rights reserved
Sponsorship
Medical Research Council (MC_UU_00015/1)
Medical Research Council (MC_EX_MR/M009858/1)
Medical Research Council (MC_U105663139)
MRC (MC_UP_1002/1)
Medical Research Council (MC_U105663141)
Medical Research Council (MC_U105663150)
Medical Research Council (MC_UU_00015/8)
MRC (MC_UU_00015/2)
MRC (MC_UU_00015/8)
Medical Research Council (MC_UP_1002/1)
Medical Research Council (MC_UU_00015/7)