Transformation of CLL to ALCL: the role of clonality studies in diagnostic molecular haematopathology.
Journal of hematopathology
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Colling, R., Royston, D., & Soilleux, E. (2016). Transformation of CLL to ALCL: the role of clonality studies in diagnostic molecular haematopathology.. Journal of hematopathology, 9 (3), 143-147. https://doi.org/10.1007/s12308-016-0280-9
© 2016, The Author(s). Clonality studies greatly assist in the diagnosis of challenging haematopathology cases. These robust and standardised tests aid the detection of clonal lymphoid populations and may assist in lymphocyte subtyping. In this case report, a gentleman presented with a high-grade transformation of a B cell neoplasm which histologically and immunophenotypically mimicked a T cell anaplastic large-cell lymphoma. With the aid of T cell and B cell receptor clonality studies, it was demonstrated that this tumour was in fact of B cell lineage. This report exemplifies the role of these increasingly used and relatively new molecular tests in unusual and difficult lymphoma presentations and highlights potential pitfalls in the interpretation of their results.
External DOI: https://doi.org/10.1007/s12308-016-0280-9
This record's URL: https://www.repository.cam.ac.uk/handle/1810/300214
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/