Show simple item record

dc.contributor.authorFalo-Sanjuan, Juliaen
dc.contributor.authorBray, Sarahen
dc.date.accessioned2019-12-21T00:30:50Z
dc.date.available2019-12-21T00:30:50Z
dc.date.issued2020-01en
dc.identifier.issn0012-1592
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/300223
dc.description.abstractNotch signalling controls many key cellular processes which differ according to the context where the pathway is deployed due the transcriptional activation of specific sets of genes. The pathway is unusual in its lack of amplification, also raising the question of how it can efficiently activate transcription with limiting amounts of nuclear activity. Here we focus on mechanisms that enable Notch to produce appropriate transcriptional responses and speculate on models that could explain the current gaps in knowledge.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherWiley
dc.rightsAll rights reserved
dc.rights.uri
dc.subjectAnimalsen
dc.subjectHumansen
dc.subjectSignal Transductionen
dc.subjectReceptors, Notchen
dc.subjectTranscriptional Activationen
dc.titleDecoding the Notch signal.en
dc.typeArticle
prism.endingPage14
prism.issueIdentifier1en
prism.publicationDate2020en
prism.publicationNameDevelopment, growth & differentiationen
prism.startingPage4
prism.volume62en
dc.identifier.doi10.17863/CAM.47296
dcterms.dateAccepted2019-12-06en
rioxxterms.versionofrecord10.1111/dgd.12644en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2020-01en
dc.contributor.orcidFalo-Sanjuan, Julia [0000-0002-3563-4789]
dc.contributor.orcidBray, Sarah [0000-0002-1642-599X]
dc.identifier.eissn1440-169X
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MR/L007177/1)
pubs.funder-project-idWellcome Trust (212207/Z/18/Z)
pubs.funder-project-idWELLCOME TRUST (109144/Z/15/Z)
cam.orpheus.successThu Jan 30 10:34:42 GMT 2020 - Embargo updated*
rioxxterms.freetoread.startdate2020-12-30


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record