Not many but much – ‘Non multa sed multum’ – is the motto chosen in 1991 by Serafino Zappacosta and the other founders of the EFIS‐EJI Advanced School of Immunology Ruggero Ceppellini. The motto was pertinent to the 29th Course of the School, held this October in Capri, where the participants enjoyed excellent lectures on the state-of-the-art of the meta-organism, that is the hybrid ecosystem made of our cells and microbes. Of important note, health and disease, including cancer, are properties of the meta-organism, and so are responses to new immunotherapies against cancer.