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dc.contributor.authorApergis-Schoute, Annemieke M
dc.contributor.authorBijleveld, Bastiaan
dc.contributor.authorGillan, Claire M
dc.contributor.authorFineberg, Naomi A
dc.contributor.authorSahakian, Barbara J
dc.contributor.authorRobbins, Trevor W
dc.description.abstractNeuroimaging research has highlighted maladaptive thalamo-cortico-striatal interactions in obsessive-compulsive disorder as well as a more general deficit in prefrontal functioning linked with compromised executive functioning. More specifically, dysfunction in the ventromedial prefrontal cortex, a central hub in coordinating flexible behaviour, is thought to be central to obsessive-compulsive disorder symptomatology. We sought to determine the intrinsic alterations of the ventromedial prefrontal cortex in obsessive-compulsive disorder employing resting-state functional connectivity magnetic resonance imaging analyses with a ventromedial prefrontal cortex seed region of interest. A total of 38 obsessive-compulsive disorder patients and 33 matched controls were included in our analyses. We found widespread ventromedial prefrontal cortex hyperconnectivity during rest in patients with obsessive-compulsive disorder, displaying increased connectivity with its own surrounding region in addition to hyperconnectivity with several areas along the thalamo-cortico-striatal loop: thalamus, caudate and frontal gyrus. Obsessive-compulsive disorder patients also exhibited increased functional connectivity from the ventromedial prefrontal cortex to temporal and occipital lobes, cerebellum and the motor cortex, reflecting ventromedial prefrontal cortex hyperconnectivity in large-scale brain networks. Furthermore, hyperconnectivity of the ventromedial prefrontal cortex and caudate correlated with obsessive-compulsive disorder symptomatology. Additionally, we used three key thalamo-cortico-striatal regions that were hyperconnected with our ventromedial prefrontal cortex seed as supplementary seed regions, revealing hypoconnectivity along the orbito- and lateral prefrontal cortex-striatal pathway. Taken together, these results confirm a central role of a hyperconnected ventromedial prefrontal cortex in obsessive-compulsive disorder, with a special role for maladaptive crosstalk with the caudate, and indications for hypoconnectivity along the lateral and orbito pathways.
dc.rightsAttribution 4.0 International
dc.sourcenlmid: 101702599
dc.sourceessn: 2398-2128
dc.subjectFunctional magnetic resonance imaging
dc.subjectResting state
dc.subjectprefrontal cortex
dc.subjectObsessive-compulsive Disorder
dc.subjectVentromedial Prefrontal Cortex
dc.titleHyperconnectivity of the ventromedial prefrontal cortex in obsessive-compulsive disorder.
pubs.funder-project-idMedical Research Council (G0001354)
pubs.funder-project-idWellcome Trust (104631/z/14/z, 104631)

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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International