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dc.contributor.authorSamanta, Romiten
dc.contributor.authorSummers, Charlotteen
dc.date.accessioned2020-01-04T00:30:35Z
dc.date.available2020-01-04T00:30:35Z
dc.date.issued2019-10en
dc.identifier.issn1069-3424
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/300384
dc.description.abstractThe major clinical presentations seen by critical care physicians are sepsis and acute respiratory distress syndrome (ARDS), both of which are heterogeneous clinical syndromes rather than specific diagnoses. The current diagnostic criteria provide little insight into the mechanisms underlying these heterogeneous syndromes and minimal progress has been made with regard to the development of therapies, despite many large randomized controlled trials being undertaken. This review outlines the advances made in improved characterization of critically-ill patients, using ARDS as an exemplar, and highlights the need for this improved patient characterization to be coupled with mechanistic science to develop therapies that target specific pathomechanisms.
dc.languageengen
dc.publisherThieme
dc.rightsAll rights reserved
dc.titleTranslational Research in Intensive Care Unit: Novel Approaches for Drug Development and Personalized Medicine.en
dc.typeArticle
prism.endingPage698
prism.issueIdentifier5en
prism.publicationDate2019en
prism.publicationNameSemin Respir Crit Care Meden
prism.startingPage687
prism.volume40en
dc.identifier.doi10.17863/CAM.47458
dcterms.dateAccepted2019-10-01en
rioxxterms.versionofrecord10.1055/s-0039-1698407en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-10en
dc.contributor.orcidSummers, Charlotte [0000-0002-7269-2873]
dc.identifier.eissn1098-9048
rioxxterms.typeJournal Article/Reviewen
cam.issuedOnline2019-12-11en
dc.identifier.urlhttps://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0039-1698407en
rioxxterms.freetoread.startdate2020-10-31


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