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Hyperpolarised 13C-MRI metabolic and functional imaging: an emerging renal MR diagnostic modality.

Accepted version
Peer-reviewed

Type

Article

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Authors

Pedersen, Michael 
Jensen, Jens Dam 
Jespersen, Bente 

Abstract

Magnetic resonance imaging (MRI) is a well-established modality for assessing renal morphology and function, as well as changes that occur during disease. However, the significant metabolic changes associated with renal disease are more challenging to assess with MRI. Hyperpolarized carbon-13 MRI is an emerging technique which provides an opportunity to probe metabolic alterations at high sensitivity by providing an increase in the signal-to-noise ratio of 20,000-fold or more. This review will highlight the current status of hyperpolarised 13C-MRI and its translation into the clinic and how it compares to metabolic measurements provided by competing technologies such as positron emission tomography (PET).

Description

Keywords

Hyperpolarisation, Kidney, MRI, Metabolism, Renal

Journal Title

Magnetic Resonance Materials in Physics, Biology and Medicine

Conference Name

Journal ISSN

0968-5243
1352-8661

Volume Title

Publisher

Springer Nature

Rights

All rights reserved
Sponsorship
Cancer Research UK (C12912/A27150)
This study was funded by Aarhus University Research Foundation and Karen Elise Jensen Foundation.