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dc.contributor.authorPedersen, Michaelen
dc.contributor.authorUrsprung, Stephanen
dc.contributor.authorJensen, Jens Damen
dc.contributor.authorJespersen, Benteen
dc.contributor.authorGallagher, Ferdiaen
dc.contributor.authorLaustsen, Christofferen
dc.date.accessioned2020-01-09T00:30:48Z
dc.date.available2020-01-09T00:30:48Z
dc.identifier.issn0968-5243
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/300623
dc.description.abstractMagnetic resonance imaging (MRI) is a well-established modality for assessing renal morphology and function, as well as changes that occur during disease. However, the significant metabolic changes associated with renal disease are more challenging to assess with MRI. Hyperpolarized carbon-13 MRI is an emerging technique which provides an opportunity to probe metabolic alterations at high sensitivity by providing an increase in the signal-to-noise ratio of 20,000-fold or more. This review will highlight the current status of hyperpolarised 13C-MRI and its translation into the clinic and how it compares to metabolic measurements provided by competing technologies such as positron emission tomography (PET).
dc.description.sponsorshipThis study was funded by Aarhus University Research Foundation and Karen Elise Jensen Foundation.
dc.languageengen
dc.publisherSpringer Nature
dc.rightsAll rights reserved
dc.rights.uri
dc.subjectHyperpolarisationen
dc.subjectKidneyen
dc.subjectMRIen
dc.subjectMetabolismen
dc.subjectRenalen
dc.titleHyperpolarised 13C-MRI metabolic and functional imaging: an emerging renal MR diagnostic modality.en
dc.typeArticle
prism.publicationNameMagnetic Resonance Materials in Physics, Biology and Medicineen
dc.identifier.doi10.17863/CAM.47697
dcterms.dateAccepted2019-11-12en
rioxxterms.versionofrecord10.1007/s10334-019-00801-yen
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-11-12en
dc.contributor.orcidUrsprung, Stephan [0000-0003-2476-178X]
dc.contributor.orcidGallagher, Ferdia [0000-0003-4784-5230]
dc.identifier.eissn1352-8661
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idCancer Research UK (C12912/A27150)
cam.issuedOnline2019-11-28en
cam.orpheus.successThu Jan 30 10:33:22 GMT 2020 - Embargo updated*
rioxxterms.freetoread.startdate2020-11-28


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