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dc.contributor.authorZalpuri, Saurabhen
dc.contributor.authorRomeijn, Basen
dc.contributor.authorAllara, Eliasen
dc.contributor.authorGoldman, Mindyen
dc.contributor.authorKamel, Hanyen
dc.contributor.authorGorlin, Jeden
dc.contributor.authorVassallo, Ralphen
dc.contributor.authorGrégoire, Yvesen
dc.contributor.authorGoto, Naokoen
dc.contributor.authorFlanagan, Peteren
dc.contributor.authorSpeedy, Joannaen
dc.contributor.authorBuser, Andreasen
dc.contributor.authorKutner, Jose Mauroen
dc.contributor.authorMagnussen, Karinen
dc.contributor.authorCastrén, Johannaen
dc.contributor.authorCuller, Lizen
dc.contributor.authorSussmann, Harryen
dc.contributor.authorPrinsze, Femmeke Jen
dc.contributor.authorBelanger, Kevinen
dc.contributor.authorCompernolle, Veerleen
dc.contributor.authorTiberghien, Pierreen
dc.contributor.authorCardenas, Jose Manuelen
dc.contributor.authorGandhi, Manish Jen
dc.contributor.authorWest, Kamille Aen
dc.contributor.authorLee, Cheuk-Kwongen
dc.contributor.authorJames, Sianen
dc.contributor.authorWells, Deanneen
dc.contributor.authorSutor, Laurie Jen
dc.contributor.authorWendel, Silvanoen
dc.contributor.authorColeman, Matthewen
dc.contributor.authorSeltsam, Axelen
dc.contributor.authorRoden, Kimberlyen
dc.contributor.authorSteele, Whitney Ren
dc.contributor.authorBohonek, Milosen
dc.contributor.authorAlcantara, Ramiren
dc.contributor.authorDi Angelantonio, Emanueleen
dc.contributor.authorvan den Hurk, Katjaen
dc.contributor.authorBEST Collaborative Study Group,en
dc.date.accessioned2020-01-11T00:30:23Z
dc.date.available2020-01-11T00:30:23Z
dc.date.issued2020-03en
dc.identifier.issn0041-1132
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/300761
dc.description.abstractBackground: Determination of blood donor hemoglobin (Hb) levels is a pre-requisite to ensure donor safety and blood product quality. We aimed to identify Hb measurement practices across blood donation services and to what extent differences associate with low-Hb deferral rates. Methods: An online survey was performed among Biomedical Excellence for Safer Transfusion (BEST) Collaborative members, extended with published data. Multivariable negative-binomial regression models were built to estimate adjusted associations of minimum donation intervals, Hb cut-offs (high, ≥13.5 g/dL in men or ≥12.5 g/dL in women, versus lower values), iron monitoring (yes/no), providing or prescribing iron supplementation (yes/no), post- versus pre-donation Hb measurement and geographical location (Asian vs rest), with low-Hb deferral rates. Results: Data were included from 38 blood services. Low-Hb deferral rates varied from 0.11% to 8.81% among men and 0.84% to 31.85% among women. Services with longer minimum donation intervals had significantly lower deferral rates among both women (rate ratio, RR 0.53, 95%CI 0.33-0.84) and men (RR 0.53, 95%CI 0.31-0.90). In women, iron supplementation was associated with lower Hb deferral rates (RR 0.47, 95%CI 0.23-0.94). Finally, being located in Asia was associated with higher low-Hb deferral rates; RR 9.10 (95%CI 3.89-21.27) for women and 6.76 (95%CI 2.45-18.68) for men. Conclusion: Differences in Hb measurement and eligibility criteria, particularly longer donation intervals and iron supplementation in women, are associated with variations in low-Hb deferral rates. These insights could help improve both blood donation service efficiency and donor care.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherWiley-Blackwell
dc.rightsAll rights reserved
dc.rights.uri
dc.subjectBEST Collaborative Study Groupen
dc.subjectHumansen
dc.subjectIronen
dc.subjectHemoglobinsen
dc.subjectHematologic Testsen
dc.subjectBlood Transfusionen
dc.subjectDonor Selectionen
dc.subjectTime Factorsen
dc.subjectBlood Donorsen
dc.subjectFemaleen
dc.subjectSurveys and Questionnairesen
dc.titleVariations in hemoglobin measurement and eligibility criteria across blood donation services are associated with differing low-hemoglobin deferral rates: a BEST Collaborative study.en
dc.typeArticle
prism.endingPage552
prism.issueIdentifier3en
prism.publicationDate2020en
prism.publicationNameTransfusionen
prism.startingPage544
prism.volume60en
dc.identifier.doi10.17863/CAM.47835
dcterms.dateAccepted2019-12-11en
rioxxterms.versionofrecord10.1111/trf.15676en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2020-03en
dc.contributor.orcidAllara, Elias [0000-0002-1634-8330]
dc.contributor.orcidDi Angelantonio, Emanuele [0000-0001-8776-6719]
dc.identifier.eissn1537-2995
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idBritish Heart Foundation (RG/13/13/30194)
pubs.funder-project-idBritish Heart Foundation (RG/18/13/33946)
cam.orpheus.successTue Mar 31 10:37:43 BST 2020 - Embargo updated*
cam.orpheus.counter2*
rioxxterms.freetoread.startdate2021-02-08


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