Show simple item record

dc.contributor.authorTong, Tammy YN
dc.contributor.authorAppleby, Paul N
dc.contributor.authorKey, Timothy J
dc.contributor.authorDahm, Christina C
dc.contributor.authorOvervad, Kim
dc.contributor.authorOlsen, Anja
dc.contributor.authorTjønneland, Anne
dc.contributor.authorKatzke, Verena
dc.contributor.authorKühn, Tilman
dc.contributor.authorBoeing, Heiner
dc.contributor.authorKarakatsani, Anna
dc.contributor.authorPeppa, Eleni
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorMasala, Giovanna
dc.contributor.authorGrioni, Sara
dc.contributor.authorPanico, Salvatore
dc.contributor.authorTumino, Rosario
dc.contributor.authorBoer, Jolanda MA
dc.contributor.authorVerschuren, WM Monique
dc.contributor.authorQuirós, J Ramón
dc.contributor.authorAgudo, Antonio
dc.contributor.authorRodríguez-Barranco, Miguel
dc.contributor.authorImaz, Liher
dc.contributor.authorChirlaque, María-Dolores
dc.contributor.authorMoreno-Iribas, Conchi
dc.contributor.authorEngström, Gunnar
dc.contributor.authorSonestedt, Emily
dc.contributor.authorLind, Marcus
dc.contributor.authorOtten, Julia
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorAune, Dagfinn
dc.contributor.authorRiboli, Elio
dc.contributor.authorWareham, Nicholas
dc.contributor.authorImamura, Fumiaki
dc.contributor.authorForouhi, Nita
dc.contributor.authorDi Angelantonio, Emanuele
dc.contributor.authorWood, Angela
dc.contributor.authorButterworth, Adam
dc.contributor.authorPerez-Cornago, Aurora
dc.date.accessioned2020-01-14T00:30:45Z
dc.date.available2020-01-14T00:30:45Z
dc.date.issued2020-07-21
dc.identifier.issn0195-668X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/300851
dc.description.abstractAIM: To investigate the associations between major foods and dietary fibre with subtypes of stroke in a large prospective cohort. METHODS AND RESULTS: We analysed data on 418 329 men and women from nine European countries, with an average of 12.7 years of follow-up. Diet was assessed using validated country-specific questionnaires which asked about habitual intake over the past year, calibrated using 24-h recalls. Multivariable-adjusted Cox regressions were used to estimate hazard ratios (HRs) for ischaemic and haemorrhagic stroke associated with consumption of red and processed meat, poultry, fish, dairy foods, eggs, cereals, fruit and vegetables, legumes, nuts and seeds, and dietary fibre. For ischaemic stroke (4281 cases), lower risks were observed with higher consumption of fruit and vegetables combined (HR; 95% CI per 200 g/day higher intake, 0.87; 0.82-0.93, P-trend < 0.001), dietary fibre (per 10 g/day, 0.77; 0.69-0.86, P-trend < 0.001), milk (per 200 g/day, 0.95; 0.91-0.99, P-trend = 0.02), yogurt (per 100 g/day, 0.91; 0.85-0.97, P-trend = 0.004), and cheese (per 30 g/day, 0.88; 0.81-0.97, P-trend = 0.008), while higher risk was observed with higher red meat consumption which attenuated when adjusted for the other statistically significant foods (per 50 g/day, 1.07; 0.96-1.20, P-trend = 0.20). For haemorrhagic stroke (1430 cases), higher risk was associated with higher egg consumption (per 20 g/day, 1.25; 1.09-1.43, P-trend = 0.002). CONCLUSION: Risk of ischaemic stroke was inversely associated with consumption of fruit and vegetables, dietary fibre, and dairy foods, while risk of haemorrhagic stroke was positively associated with egg consumption. The apparent differences in the associations highlight the importance of examining ischaemic and haemorrhagic stroke subtypes separately.
dc.description.sponsorshipAnalyses were supported by the UK Medical Research Council (MR/M012190/1), Cancer Research UK (C8221/A19170 and 570/A16491), and the Wellcome Trust (Our Planet Our Health, Livestock Environment and People 205212/Z/16/Z). EPIC-CVD has been supported by the European Union Framework 7 (HEALTH-F2-2012-279233), the European Research Council (268834), the UK Medical Research Council (G0800270 and MR/L003120/1), the British Heart Foundation (SP/09/002 and RG/08/014 and RG13/13/30194), and the UK National Institute of Health Research. The establishment of the study subcohort was supported by the EU Sixth Framework Programme (FP6) (grant LSHM_CT_2006_037197 to the InterAct project) and the Medical Research Council Epidemiology Unit (grants MC_UU_12015/1 and MC_UU_12015/5).
dc.format.mediumPrint
dc.languageeng
dc.publisherOxford University Press (OUP)
dc.rightsAll rights reserved
dc.subjectAnimals
dc.subjectHumans
dc.subjectBrain Ischemia
dc.subjectDiet
dc.subjectRisk Factors
dc.subjectProspective Studies
dc.subjectDietary Fiber
dc.subjectEurope
dc.subjectFemale
dc.subjectMale
dc.subjectStroke
dc.subjectHemorrhagic Stroke
dc.titleThe associations of major foods and fibre with risks of ischaemic and haemorrhagic stroke: a prospective study of 418 329 participants in the EPIC cohort across nine European countries.
dc.typeArticle
prism.endingPage2640
prism.issueIdentifier28
prism.publicationDate2020
prism.publicationNameEur Heart J
prism.startingPage2632
prism.volume41
dc.identifier.doi10.17863/CAM.47928
dcterms.dateAccepted2020-01-10
rioxxterms.versionofrecord10.1093/eurheartj/ehaa007
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2020-07
dc.contributor.orcidWareham, Nicholas [0000-0003-1422-2993]
dc.contributor.orcidImamura, Fumiaki [0000-0002-6841-8396]
dc.contributor.orcidForouhi, Nita [0000-0002-5041-248X]
dc.contributor.orcidDi Angelantonio, Emanuele [0000-0001-8776-6719]
dc.contributor.orcidWood, Angela [0000-0002-7937-304X]
dc.contributor.orcidButterworth, Adam [0000-0002-6915-9015]
dc.identifier.eissn1522-9645
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MC_UU_12015/5)
pubs.funder-project-idMedical Research Council (MC_UU_12015/1)
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (NF-SI-0617-10149)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (146281)
pubs.funder-project-idMedical Research Council (G0401527)
pubs.funder-project-idMedical Research Council (MR/N003284/1)
pubs.funder-project-idMedical Research Council (G1000143)
pubs.funder-project-idMedical Research Council (G0800270)
pubs.funder-project-idEuropean Research Council (268834)
pubs.funder-project-idMedical Research Council (MR/L003120/1)
pubs.funder-project-idBritish Heart Foundation (None)
pubs.funder-project-idMedical Research Council (G0700463)
pubs.funder-project-idMRC (MC_UU_00006/1)
pubs.funder-project-idMRC (MC_UU_00006/3)
cam.issuedOnline2020-02-24
cam.orpheus.successTue Mar 31 10:37:38 BST 2020 - Embargo updated
cam.orpheus.counter2
rioxxterms.freetoread.startdate2023-01-13


Files in this item

Thumbnail
Thumbnail
Thumbnail
Thumbnail
Thumbnail
Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record