Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.
Accepted version
Peer-reviewed
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Repository DOI
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Authors
Demenais, Florence
Margaritte-Jeannin, Patricia
Barnes, Kathleen C
Cookson, William OC
Altmüller, Janine
Abstract
We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma loci, established asthma associations at two loci previously implicated in the comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. The enrichment in enhancer marks at asthma risk loci, especially in immune cells, suggested a major role of these loci in the regulation of immunologically related mechanisms.
Description
Keywords
Alleles, Asthma, Enhancer Elements, Genetic, Epigenesis, Genetic, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Histone Code, Humans, Leukocytes, Phenotype, Promoter Regions, Genetic, Rhinitis, Allergic, Seasonal, Risk
Journal Title
Nature Genetics
Conference Name
Journal ISSN
1061-4036
1546-1718
1546-1718
Volume Title
50
Publisher
Springer Nature
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All rights reserved
Sponsorship
Medical Research Council (MC_UU_12015/1)
MRC (MC_PC_13048)
Department of Health (via National Institute for Health Research (NIHR)) (NF-SI-0512-10135)
Department of Health (via National Institute for Health Research (NIHR)) (NF-SI-0617-10149)
MRC (MC_PC_13048)
Department of Health (via National Institute for Health Research (NIHR)) (NF-SI-0512-10135)
Department of Health (via National Institute for Health Research (NIHR)) (NF-SI-0617-10149)