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Calcitonin Receptor Neurons in the Mouse Nucleus Tractus Solitarius Control Energy Balance via the Non-aversive Suppression of Feeding.

Published version
Peer-reviewed

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Authors

Cheng, Wenwen 
Gonzalez, Ian 
Pan, Warren 
Tsang, Anthony H 
Adams, Jessica 

Abstract

To understand hindbrain pathways involved in the control of food intake, we examined roles for calcitonin receptor (CALCR)-containing neurons in the NTS. Ablation of NTS Calcr abrogated the long-term suppression of food intake, but not aversive responses, by CALCR agonists. Similarly, activating CalcrNTS neurons decreased food intake and body weight but (unlike neighboring CckNTS cells) failed to promote aversion, revealing that CalcrNTS neurons mediate a non-aversive suppression of food intake. While both CalcrNTS and CckNTS neurons decreased feeding via projections to the PBN, CckNTS cells activated aversive CGRPPBN cells while CalcrNTS cells activated distinct non-CGRP PBN cells. Hence, CalcrNTS cells suppress feeding via non-aversive, non-CGRP PBN targets. Additionally, silencing CalcrNTS cells blunted food intake suppression by gut peptides and nutrients, increasing food intake and promoting obesity. Hence, CalcrNTS neurons define a hindbrain system that participates in physiological energy balance and suppresses food intake without activating aversive systems.

Description

Keywords

NTS, PBN, anorexia, aversion, calcitonin receptor, obesity, Animals, Body Weight, Eating, Energy Metabolism, Female, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Neurons, Receptors, Calcitonin, Solitary Nucleus

Journal Title

Cell Metab

Conference Name

Journal ISSN

1550-4131
1932-7420

Volume Title

31

Publisher

Elsevier BV
Sponsorship
Wellcome Trust (100574/Z/12/Z)
Medical Research Council (MC_UU_12012/1)
Medical Research Council (MC_UU_12012/5)
Medical Research Council (MR/N003276/1)
Wellcome Trust (204845/Z/16/Z)
MRC (MC_UU_00014/6)
MRC (MC_UU_00014/5)
MRC (MR/M501736/1)
Medical Research Council (MC_PC_12012)