Functional reorganisation and recovery following cortical lesions: A preliminary study in macaque monkeys.
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Authors
Ainsworth, Matthew
Browncross, Helen
Mitchell, Anna S
Passingham, Richard E
Buckley, Mark J
Duncan, John
Publication Date
2018-10Journal Title
Neuropsychologia
ISSN
0028-3932
Publisher
Elsevier BV
Volume
119
Pages
382-391
Language
eng
Type
Article
This Version
VoR
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Ainsworth, M., Browncross, H., Mitchell, D., Mitchell, A. S., Passingham, R. E., Buckley, M. J., Duncan, J., & et al. (2018). Functional reorganisation and recovery following cortical lesions: A preliminary study in macaque monkeys.. Neuropsychologia, 119 382-391. https://doi.org/10.1016/j.neuropsychologia.2018.08.024
Abstract
Damage following traumatic brain injury or stroke can often extend beyond the boundaries of the initial insult and can lead to maladaptive cortical reorganisation. On the other hand, beneficial cortical reorganisation leading to recovery of function can also occur. We used resting state FMRI to investigate how cortical networks in the macaque brain change across time in response to lesions to the prefrontal cortex, and how this reorganisation correlated with changes in behavioural performance in cognitive tasks. After prelesion testing and scanning, two monkeys received a lesion to regions surrounding the left principal sulcus followed by periodic testing and scanning. Later, the animals received another lesion to the opposite hemisphere and additional testing and scanning. Following the first lesion, we observed both a behavioural impairment and decrease in functional connectivity, predominantly in frontal-frontal networks. Approximately 8 weeks later, performance and connectivity patterns both improved. Following the second lesion, we observed a further behavioural deficit and decrease in connectivity that showed little recovery. We discuss how different mechanisms including alternate behavioural strategies and reorganisation of specific prefrontal networks may have led to improvements in behaviour. Further work will be needed to confirm these mechanisms.
Keywords
Hand, Prefrontal Cortex, Neural Pathways, Animals, Macaca mulatta, Magnetic Resonance Imaging, Brain Mapping, Longitudinal Studies, Motor Activity, Memory, Space Perception, Visual Perception, Recovery of Function, Neuronal Plasticity, Rest, Male, Preliminary Data
Sponsorship
This work was supported by the MRC intramural program MC-A060-5PQ10 (MA, DM, JD, AB), an MRC Career Development Award G0800329 (AM).
Funder references
MRC (unknown)
Medical Research Council (MC_UU_00005/6)
Identifiers
External DOI: https://doi.org/10.1016/j.neuropsychologia.2018.08.024
This record's URL: https://www.repository.cam.ac.uk/handle/1810/301182
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