Functional reorganisation and recovery following cortical lesions: A preliminary study in macaque monkeys.
Mitchell, Anna S
Passingham, Richard E
Buckley, Mark J
Oxford University Press
MetadataShow full item record
Ainsworth, M., Browncross, H., Mitchell, D., Mitchell, A. S., Passingham, R. E., Buckley, M. J., Duncan, J., & et al. (2018). Functional reorganisation and recovery following cortical lesions: A preliminary study in macaque monkeys.. Neuropsychologia, 119 382-391. https://doi.org/10.1016/j.neuropsychologia.2018.08.024
Damage following traumatic brain injury or stroke can often extend beyond the boundaries of the initial insult and can lead to maladaptive cortical reorganisation. On the other hand, beneficial cortical reorganisation leading to recovery of function can also occur. Here,we used resting state FMRI (rsFMRI) to examine how functional connectivity in the macaque brain changed across time in response to lesions to the prefrontal cortex, and how this reorganisation correlated with changes in behaviour. Two monkeys were trained to perform location-based and object-based delayed match-to-sample tasks. We also collected rsFMRI data under general anaesthesia at two pre-lesion time-points,separated by 3-4 weeks. After two cycles of testing and scanning, the animals received a principal sulcus lesion followed by an additional 4 cycles of testing and scanning. Later, the same animals received a second lesion to the opposite hemisphere and additional cycles of testing and scanning. Both animals showed a marked behavioural impairment following the first lesion, which was associated with a decrease in functional connectivity, predominantly within frontal-frontal networks in both hemispheres. Approximately 8 weeks following the lesion, performance improved, as did functional connectivity within these networks. Following the second lesion, functional connectivity again decreased and this was associated with a marginal behavioural deficit that did not recover. Our data show that behavioural impairments reflect not just the removal of the lesioned area, but also disturbance to an extensive cortical network. This network can recover by restoring and/or strengthening pre-existing connections, leading to improvement in behaviour.
Hand, Prefrontal Cortex, Neural Pathways, Animals, Macaca mulatta, Magnetic Resonance Imaging, Brain Mapping, Longitudinal Studies, Motor Activity, Memory, Space Perception, Visual Perception, Recovery of Function, Neuronal Plasticity, Rest, Male, Preliminary Data
This work was supported by the MRC intramural program MC-A060-5PQ10 (MA, DM, JD, AB), an MRC Career Development Award G0800329 (AM).
External DOI: https://doi.org/10.1016/j.neuropsychologia.2018.08.024
This record's URL: https://www.repository.cam.ac.uk/handle/1810/301182
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/