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dc.contributor.authorCouto Alves, Alexessander
dc.contributor.authorDe Silva, N Maneka G
dc.contributor.authorKarhunen, Ville
dc.contributor.authorSovio, Ulla
dc.contributor.authorDas, Shikta
dc.contributor.authorTaal, H Rob
dc.contributor.authorWarrington, Nicole M
dc.contributor.authorLewin, Alexandra M
dc.contributor.authorKaakinen, Marika
dc.contributor.authorCousminer, Diana L
dc.contributor.authorThiering, Elisabeth
dc.contributor.authorTimpson, Nicholas J
dc.contributor.authorBond, Tom A
dc.contributor.authorLowry, Estelle
dc.contributor.authorBrown, Christopher D
dc.contributor.authorEstivill, Xavier
dc.contributor.authorLindi, Virpi
dc.contributor.authorBradfield, Jonathan P
dc.contributor.authorGeller, Frank
dc.contributor.authorSpeed, Doug
dc.contributor.authorCoin, Lachlan J M
dc.contributor.authorLoh, Marie
dc.contributor.authorBarton, Sheila J
dc.contributor.authorBeilin, Lawrence J
dc.contributor.authorBisgaard, Hans
dc.contributor.authorBønnelykke, Klaus
dc.contributor.authorAlili, Rohia
dc.contributor.authorHatoum, Ida J
dc.contributor.authorSchramm, Katharina
dc.contributor.authorCartwright, Rufus
dc.contributor.authorCharles, Marie-Aline
dc.contributor.authorSalerno, Vincenzo
dc.contributor.authorClément, Karine
dc.contributor.authorClaringbould, Annique A J
dc.contributor.authorvan Duijn, Cornelia M
dc.contributor.authorMoltchanova, Elena
dc.contributor.authorEriksson, Johan G
dc.contributor.authorElks, Cathy
dc.contributor.authorFeenstra, Bjarke
dc.contributor.authorFlexeder, Claudia
dc.contributor.authorFranks, Stephen
dc.contributor.authorFrayling, Timothy M
dc.contributor.authorFreathy, Rachel M
dc.contributor.authorElliott, Paul
dc.contributor.authorWidén, Elisabeth
dc.contributor.authorHakonarson, Hakon
dc.contributor.authorHattersley, Andrew T
dc.contributor.authorRodriguez, Alina
dc.contributor.authorBanterle, Marco
dc.contributor.authorHeinrich, Joachim
dc.contributor.authorHeude, Barbara
dc.contributor.authorHolloway, John W
dc.contributor.authorHofman, Albert
dc.contributor.authorHyppönen, Elina
dc.contributor.authorInskip, Hazel
dc.contributor.authorKaplan, Lee M
dc.contributor.authorHedman, Asa K
dc.contributor.authorLäärä, Esa
dc.contributor.authorProkisch, Holger
dc.contributor.authorGrallert, Harald
dc.contributor.authorLakka, Timo A
dc.contributor.authorLawlor, Debbie A
dc.contributor.authorMelbye, Mads
dc.contributor.authorAhluwalia, Tarunveer S
dc.contributor.authorMarinelli, Marcella
dc.contributor.authorMillwood, Iona Y
dc.contributor.authorPalmer, Lyle J
dc.contributor.authorPennell, Craig E
dc.contributor.authorPerry, John R
dc.contributor.authorRing, Susan M
dc.contributor.authorSavolainen, Markku J
dc.contributor.authorRivadeneira, Fernando
dc.contributor.authorStandl, Marie
dc.contributor.authorSunyer, Jordi
dc.contributor.authorTiesler, Carla M T
dc.contributor.authorUitterlinden, Andre G
dc.contributor.authorSchierding, William
dc.contributor.authorO'Sullivan, Justin M
dc.contributor.authorProkopenko, Inga
dc.contributor.authorHerzig, Karl-Heinz
dc.contributor.authorSmith, George Davey
dc.contributor.authorO'Reilly, Paul
dc.contributor.authorFelix, Janine F
dc.contributor.authorBuxton, Jessica L
dc.contributor.authorBlakemore, Alexandra I F
dc.contributor.authorOng, Ken K
dc.contributor.authorJaddoe, Vincent W V
dc.contributor.authorGrant, Struan F A
dc.contributor.authorSebert, Sylvain
dc.contributor.authorMcCarthy, Mark I
dc.contributor.authorJärvelin, Marjo-Riitta
dc.date.accessioned2020-01-25T01:55:30Z
dc.date.available2020-01-25T01:55:30Z
dc.date.issued2019-09-04
dc.identifier.issn2375-2548
dc.identifier.other31840077
dc.identifier.otherPMC6904961
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/301252
dc.description.abstractEarly childhood growth patterns are associated with adult health, yet the genetic factors and the developmental stages involved are not fully understood. Here, we combine genome-wide association studies with modeling of longitudinal growth traits to study the genetics of infant and child growth, followed by functional, pathway, genetic correlation, risk score, and colocalization analyses to determine how developmental timings, molecular pathways, and genetic determinants of these traits overlap with those of adult health. We found a robust overlap between the genetics of child and adult body mass index (BMI), with variants associated with adult BMI acting as early as 4 to 6 years old. However, we demonstrated a completely distinct genetic makeup for peak BMI during infancy, influenced by variation at the LEPR/LEPROT locus. These findings suggest that different genetic factors control infant and child BMI. In light of the obesity epidemic, these findings are important to inform the timing and targets of prevention strategies.
dc.languageeng
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 2375-2548
dc.sourcenlmid: 101653440
dc.titleGWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI.
dc.typeArticle
dc.date.updated2020-01-25T01:55:30Z
dc.identifier.doi10.17863/CAM.48335
rioxxterms.versionofrecord10.1126/sciadv.aaw3095
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidSovio, Ulla [0000-0002-0799-1105]
dc.contributor.orcidWarrington, Nicole M [0000-0003-4195-775X]
dc.contributor.orcidLewin, Alexandra M [0000-0003-0081-7582]
dc.contributor.orcidKaakinen, Marika [0000-0002-9228-0462]
dc.contributor.orcidCousminer, Diana L [0000-0001-8864-7893]
dc.contributor.orcidTimpson, Nicholas J [0000-0002-7141-9189]
dc.contributor.orcidLowry, Estelle [0000-0002-4655-416X]
dc.contributor.orcidBrown, Christopher D [0000-0002-3785-5008]
dc.contributor.orcidEstivill, Xavier [0000-0002-0723-2256]
dc.contributor.orcidGeller, Frank [0000-0002-9238-3269]
dc.contributor.orcidSpeed, Doug [0000-0002-0096-9765]
dc.contributor.orcidCoin, Lachlan J M [0000-0002-4300-455X]
dc.contributor.orcidLoh, Marie [0000-0003-3626-8466]
dc.contributor.orcidBarton, Sheila J [0000-0003-4963-4242]
dc.contributor.orcidAlili, Rohia [0000-0002-0158-4250]
dc.contributor.orcidSchramm, Katharina [0000-0002-8809-3170]
dc.contributor.orcidCharles, Marie-Aline [0000-0003-4025-4390]
dc.contributor.orcidClaringbould, Annique A J [0000-0002-9201-6557]
dc.contributor.orcidvan Duijn, Cornelia M [0000-0002-2374-9204]
dc.contributor.orcidFeenstra, Bjarke [0000-0003-1478-649X]
dc.contributor.orcidFrayling, Timothy M [0000-0001-8362-2603]
dc.contributor.orcidFreathy, Rachel M [0000-0003-4152-2238]
dc.contributor.orcidWidén, Elisabeth [0000-0001-7108-2806]
dc.contributor.orcidHakonarson, Hakon [0000-0003-2814-7461]
dc.contributor.orcidRodriguez, Alina [0000-0003-1209-8802]
dc.contributor.orcidHeude, Barbara [0000-0002-1565-1629]
dc.contributor.orcidHolloway, John W [0000-0001-9998-0464]
dc.contributor.orcidHofman, Albert [0000-0002-9865-121X]
dc.contributor.orcidHyppönen, Elina [0000-0003-3670-9399]
dc.contributor.orcidInskip, Hazel [0000-0001-8897-1749]
dc.contributor.orcidKaplan, Lee M [0000-0002-6301-2696]
dc.contributor.orcidProkisch, Holger [0000-0003-2379-6286]
dc.contributor.orcidLakka, Timo A [0000-0002-9199-2871]
dc.contributor.orcidLawlor, Debbie A [0000-0002-6793-2262]
dc.contributor.orcidMelbye, Mads [0000-0001-8264-6785]
dc.contributor.orcidAhluwalia, Tarunveer S [0000-0002-7464-3354]
dc.contributor.orcidMarinelli, Marcella [0000-0002-5450-3960]
dc.contributor.orcidPalmer, Lyle J [0000-0002-1628-3055]
dc.contributor.orcidPennell, Craig E [0000-0002-0937-6165]
dc.contributor.orcidPerry, John R [0000-0001-6483-3771]
dc.contributor.orcidRing, Susan M [0000-0003-3103-9330]
dc.contributor.orcidSavolainen, Markku J [0000-0002-2557-6423]
dc.contributor.orcidRivadeneira, Fernando [0000-0001-9435-9441]
dc.contributor.orcidSunyer, Jordi [0000-0002-2602-4110]
dc.contributor.orcidSchierding, William [0000-0001-5659-2701]
dc.contributor.orcidO'Sullivan, Justin M [0000-0003-2927-450X]
dc.contributor.orcidProkopenko, Inga [0000-0003-1624-7457]
dc.contributor.orcidSmith, George Davey [0000-0002-1407-8314]
dc.contributor.orcidFelix, Janine F [0000-0002-9801-5774]
dc.contributor.orcidOng, Ken K [0000-0003-4689-7530]
dc.contributor.orcidJaddoe, Vincent W V [0000-0003-2939-0041]
dc.contributor.orcidSebert, Sylvain [0000-0001-6681-6983]
dc.contributor.orcidMcCarthy, Mark I [0000-0002-4393-0510]
dc.contributor.orcidJärvelin, Marjo-Riitta [0000-0002-2149-0630]
pubs.funder-project-idLundbeck Foundation (R163-2013-16235)
pubs.funder-project-idWellcome Trust (102215, WT205915)


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International