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Dopaminergic modulation of reinforcement learning in stimulant drug addiction

Accepted version
Peer-reviewed

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Type

Conference Object

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Authors

Lim, TV 
Cardinal, RN 
Meng, C 
Murray, GK 
Craig, KJ 

Abstract

Background: Chronic stimulant use has been associated with disruptions in fronto-striatal systems implicated in as- sociative learning [1]. Experimental studies have also shown that individuals with stimulant drug addiction experience difficulties in selecting the appropriate action following feedback [2]. However, the precise impairments in feedback learning in stimulant-addicted individuals are still unclear. A possible explanation might lie in an abnormal prediction error mechanism, as stimulant drugs directly target striatal dopaminergic neurons [3].

Description

Keywords

5202 Biological Psychology, 32 Biomedical and Clinical Sciences, 3209 Neurosciences, 52 Psychology

Journal Title

EUROPEAN NEUROPSYCHOPHARMACOLOGY

Conference Name

32nd ECNP Congress

Journal ISSN

0924-977X
1873-7862

Volume Title

29

Publisher

Elsevier BV

Rights

All rights reserved
Sponsorship
Medical Research Council (MC_PC_17213)
Wellcome Trust; support from NIHR Cambridge BRC