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dc.contributor.authorHewitt, Rachelen
dc.contributor.authorChappell, Helenen
dc.contributor.authorPowell, Jonathanen
dc.date.accessioned2020-02-01T00:31:56Z
dc.date.available2020-02-01T00:31:56Z
dc.date.issued2020-02en
dc.identifier.issn2468-2020
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/301586
dc.description.abstractWe are continuously exposed to large numbers of non-biological, persistent particulates through dermal, oral and inhalation routes. At sizes perfect for cell interactions, such modern particle exposures are derived from human engineering either purposefully (e.g. additives/excipients) or inadvertently (e.g. pollution). Whether oral or dermal exposure to common particles has significantly adverse effects is not yet known. However, relationships between increased morbidity or mortality and airborne particle exposure are well established. Large nanoparticles and microparticles adsorb environmental molecules, including antigens and allergens, and deliver them to cells potentially with an adjuvant effect. Smaller nanoparticles may have enhanced redox activity due to increased surface areas or band gap effects. Under some circumstances, ultrasmall nanoparticles can ligate cellular receptors or interact with other cell machinery and drive distinct cell signalling. These, as well as the potential for inflammasome activation, are discussed as feasible pathways to understanding or de-bunking particle toxicity.
dc.description.sponsorshipWe would like to thank the UK Medical Research Council (Grant number MR/R005699/1) for their support.
dc.publisherElsevier
dc.rightsAll rights reserved
dc.rights.uri
dc.titleSmall and dangerous? Potential toxicity mechanisms of common exposure particles and nanoparticles.en
dc.typeArticle
prism.endingPage98
prism.publicationDate2020en
prism.publicationNameCurrent Opinion in Toxicologyen
prism.startingPage93
prism.volume19en
dc.identifier.doi10.17863/CAM.48655
dcterms.dateAccepted2020-01-24en
rioxxterms.versionofrecord10.1016/j.cotox.2020.01.006en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
rioxxterms.licenseref.startdate2020-02en
dc.contributor.orcidHewitt, Rachel [0000-0002-2367-1822]
dc.contributor.orcidPowell, Jonathan [0000-0003-2738-1715]
dc.identifier.eissn2468-2020
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MR/R005699/1)
cam.issuedOnline2020-01-30en
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S2468202020300085?via%3Dihub#!en
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