PCSK6-Mediated Regulation of Vascular Remodeling.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Jørgensen, Helle F
Bennett, Martin R
Abstract
Genetic association studies have significantly enhanced our understanding of vascular disease aetiology, and offer great promise for identification of candidate drug targets and estimating disease risk1. In a study recently published in Circulation Research, Rykaczewska et al2 have used the IMPROVE database (n=3378), AtheroExpress biobank (n=197) and BiKE cohorts (n=127) to convincingly demonstrate that rs1531817, a non-coding intronic variant in the PCSK6 locus, is associated with decreased PCSK6 expression and increased vascular disease severity.
Description
Keywords
Editorials, atherosclerosis, cell proliferation, homeostasis, hyperplasia, vascular smooth muscle cell, Humans, Muscle, Smooth, Vascular, Myocytes, Smooth Muscle, Peptide Hydrolases, Proprotein Convertases, Serine Endopeptidases, Vascular Remodeling
Journal Title
Circ Res
Conference Name
Journal ISSN
0009-7330
1524-4571
1524-4571
Volume Title
126
Publisher
Ovid Technologies (Wolters Kluwer Health)
Publisher DOI
Rights
All rights reserved
Sponsorship
British Heart Foundation (RE/18/1/34212)
British Heart Foundation (CH/2000003/12800)
British Heart Foundation (FS/15/38/31516)
British Heart Foundation (PG/19/6/34153)
British Heart Foundation (RG/20/2/34763)
British Heart Foundation (CH/2000003/12800)
British Heart Foundation (FS/15/38/31516)
British Heart Foundation (PG/19/6/34153)
British Heart Foundation (RG/20/2/34763)
British Heart Foundation (BHF) grants RE/18/1/34212, AVRO01830/RM/17/2/33380, PG/19/6/34153, CH/2000003