Hepatic microRNA Expression by PGC-1α and PGC-1β in the Mouse.
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Piccinin, Elena https://orcid.org/0000-0002-6514-2689
Arconzo, Maria
Graziano, Giusi
Vacca, Michele https://orcid.org/0000-0002-1973-224X
Peres, Claudia
Abstract
The fine-tuning of liver metabolism is essential to maintain the whole-body homeostasis and to prevent the onset of diseases. The peroxisome proliferator-activated receptor-γ coactivators (PGC-1s) are transcriptional key players of liver metabolism, able to regulate mitochondrial function, gluconeogenesis and lipid metabolism. Their activity is accurately modulated by post-translational modifications. Here, we showed that specific PGC-1s expression can lead to the upregulation of different microRNAs widely implicated in liver physiology and diseases development and progression, thus offering a new layer of complexity in the control of hepatic metabolism.
Description
Keywords
PGC-1, coactivators, liver diseases, liver metabolism, microRNA, Animals, Female, Liver, Liver Diseases, Mice, MicroRNAs, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Real-Time Polymerase Chain Reaction
Journal Title
Int J Mol Sci
Conference Name
Journal ISSN
1661-6596
1422-0067
1422-0067
Volume Title
20
Publisher
MDPI AG