Show simple item record

dc.contributor.authorPeretti, Diego
dc.contributor.authorKim, SoHui
dc.contributor.authorTufi, Roberta
dc.contributor.authorLev, Sima
dc.date.accessioned2020-02-06T05:13:32Z
dc.date.available2020-02-06T05:13:32Z
dc.date.issued2020-01-23
dc.date.submitted2019-09-23
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/301774
dc.description.abstractLipid-transfer proteins (LTPs) were initially discovered as cytosolic factors that facilitate lipid transport between membrane bilayers in vitro. Since then, many LTPs have been isolated from bacteria, plants, yeast, and mammals, and extensively studied in cell-free systems and intact cells. A major advance in the LTP field was associated with the discovery of intracellular membrane contact sites (MCSs), small cytosolic gaps between the endoplasmic reticulum (ER) and other cellular membranes, which accelerate lipid transfer by LTPs. As LTPs modulate the distribution of lipids within cellular membranes, and many lipid species function as second messengers in key signaling pathways that control cell survival, proliferation, and migration, LTPs have been implicated in cancer-associated signal transduction cascades. Increasing evidence suggests that LTPs play an important role in cancer progression and metastasis. This review describes how different LTPs as well as MCSs can contribute to cell transformation and malignant phenotype, and discusses how “aberrant” MCSs are associated with tumorigenesis in human.
dc.languageen
dc.publisherFrontiers Media S.A.
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectCell and Developmental Biology
dc.subjectLTPs
dc.subjectMCSs
dc.subjectcancer
dc.subjectcalcium
dc.subjectlipids
dc.titleLipid Transfer Proteins and Membrane Contact Sites in Human Cancer
dc.typeArticle
dc.date.updated2020-02-06T05:13:32Z
prism.publicationNameFrontiers in Cell and Developmental Biology, volume 7
dc.identifier.doi10.17863/CAM.48848
dcterms.dateAccepted2019-12-16
rioxxterms.versionofrecord10.3389/fcell.2019.00371
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.identifier.eissn2296-634X


Files in this item

Thumbnail
Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)