Show simple item record

dc.contributor.authorBrowne, Andrewen
dc.contributor.authorFisher, Sheila Aen
dc.contributor.authorMasconi, Katyaen
dc.contributor.authorSmith, Grahamen
dc.contributor.authorDoree, Carolynen
dc.contributor.authorChung, Ryanen
dc.contributor.authorRahimzadeh, Manaen
dc.contributor.authorShah, Akshayen
dc.contributor.authorRodriguez, Silvia Alonsoen
dc.contributor.authorBolton, Thomasen
dc.contributor.authorKaptoge, Stephenen
dc.contributor.authorWood, Angelaen
dc.contributor.authorSweeting, Michaelen
dc.contributor.authorRoberts, David Jen
dc.date.accessioned2020-02-06T08:50:24Z
dc.date.available2020-02-06T08:50:24Z
dc.date.issued2020-01-01en
dc.identifier.issn0887-7963
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/301775
dc.description.abstractBlood donors attending a donation session may be deferred from donating blood due to a failure to meet low hemoglobin (Hb) thresholds. This costs the blood donor service and donors valuable time and resources. In addition, donors who are deferred may have more symptoms, and as a direct and/or indirect effect of their experience, return rates of donors deferred for low Hb are reduced, even in repeat donors. It is therefore vital that low Hb deferral (LHD) is minimized. The aim of this updated systematic review is to expand the evidence base for factors which affect a donor's risk of deferral due to low Hb. Studies were identified by searching MEDLINE, Embase, The Cochrane Library, and the WHO International Clinical Trials Registry to March 2019. Demographic data, donor history, hematological/biological factors, and the primary outcome of deferral due to low Hb were extracted. Our primary outcome was deferral due to low Hb. Analyses were descriptive and quantitative; pooled odds ratios (ORs) and 95% confidence intervals (CIs) were obtained by meta-analysis using random-effects models. A total of 116 studies met the inclusion criteria. Meta-analysis showed a significantly greater risk of LHD in females compared with males in studies applying universal Hb thresholds for males and females (OR 14.62 95% CI 12.43-17.19) and in those which used sex-specific thresholds (OR 5.73, 95% CI 4.36-7.53). Higher rates of LHD were also associated with increasing age in men, low body weight, shorter interdonation interval, donors of Hispanic or African descent, higher ambient temperature, donors with low ferritin levels, and donation in a fixed donor center. There was conflicting evidence on the effect of new and repeat donor status, and blood group. This work has strengthened the evidence of the previous review in identifying factors that should be considered in studies of donor deferral and highlighting areas in need of further study, including ABO and Rh blood groups, previous platelet donation, diet, smoking, time of day, and genetic data. These factors may lead to individually tailored donation criteria for safe and efficient donation in the future.
dc.description.sponsorshipThis research is supported by core funding from NHS Blood and Transplant, the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre Programme (SF, CD), the UK Medical Research Council (MR/L003120/1), the British Heart Foundation (RG/13/13/30194; RG/18/13/33946), and the National Institute for Health Research [Cambridge Biomedical Research Centre at the Cambridge University Hospitals NHS Foundation Trust]. AB, TB, and KM are funded by the NIHR Blood and Transplant Research Unit in Donor Health and Genomics (NIHR BTRU-2014-10024). SAR is funded by the National Institute for Health Research [Cambridge Biomedical Research Centre at the Cambridge University Hospitals NHS Foundation Trust].
dc.languageengen
dc.publisherElsevier
dc.rightsAll rights reserved
dc.subjectAnemiaen
dc.subjectBlood donationen
dc.subjectBlood donorsen
dc.subjectDeferralen
dc.subjectHemoglobinen
dc.titleDonor Deferral Due to Low Hemoglobin-An Updated Systematic Review.en
dc.typeArticle
prism.endingPage22
prism.issueIdentifier1en
prism.publicationDate2020en
prism.publicationNameTransfusion Medicine Reviewsen
prism.startingPage10
prism.volume34en
dc.identifier.doi10.17863/CAM.48849
dcterms.dateAccepted2019-10-02en
rioxxterms.versionofrecord10.1016/j.tmrv.2019.10.002en
rioxxterms.versionAM*
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2020-01-01en
dc.contributor.orcidKaptoge, Stephen [0000-0002-1155-4872]
dc.contributor.orcidWood, Angela [0000-0002-7937-304X]
dc.identifier.eissn1532-9496
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (unknown)
pubs.funder-project-idBritish Heart Foundation (CH/12/2/29428)
pubs.funder-project-idMRC (MR/L003120/1)
pubs.funder-project-idBritish Heart Foundation (RG/13/13/30194)
pubs.funder-project-idBritish Heart Foundation (RG/18/13/33946)
cam.issuedOnline2019-10-31en
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0887796319301373?via%3Dihub#!en
cam.orpheus.successTue Mar 31 10:37:19 BST 2020 - Embargo updated*
rioxxterms.freetoread.startdate2020-10-31


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record