Acoustic biosensing using functionalised microbubbles
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In this work, functionalised microbubbles are investigated as a new platform for acoustic biosensing. In medical ultrasound, encapsulated microbubbles (MBs) are injected into the body to enhance contrast between blood and surrounding tissue. Microbubbles are not only good ultrasound scatterers: when placed in an ultrasound field, they act as non-linear resonators, generating harmonic energies in the scattered acoustic signal, and this can be further exploited for biosensing. Analytical models and finite element method (FEM) simulations for the interaction between high frequency (1-300 MHz) acoustic waves and encapsulated microbubbles, show that an incident acoustic wave can set a microbubble into mechanical resonance. The resonant frequency is strongly dependent on the shell properties (thickness, elasticity, viscosity,
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Hall, Elizabeth (Lisa) Anne Howlett