Prospective Associations of Accelerometer-Measured Physical Activity and Sedentary Time With Incident Cardiovascular Disease, Cancer, and All-Cause Mortality.
Wolters Kluwer Health
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Dempsey, P., Strain, T., Khaw, K., Wareham, N., Brage, S., & Wijndaele, K. (2020). Prospective Associations of Accelerometer-Measured Physical Activity and Sedentary Time With Incident Cardiovascular Disease, Cancer, and All-Cause Mortality.. Circulation, 141 (13), 1113-1115. https://doi.org/10.1161/circulationaha.119.043030
Insufficient moderate-to-vigorous-intensity physical activity (MVPA) and high volumes of sedentary time (ST) have both been associated with increased risk of all-cause mortality, cardiovascular disease (CVD), and some cancers1. However, epidemiological evidence has mostly relied on self-reported physical activity (PA) measures, which are prone to reporting bias and measurement error. Cohort studies incorporating objective assessments of PA are emerging2-4; but few investigate relationships of accelerometer-measured PA and ST with clinical endpoints, particularly incident CVD, and include both men and women5. Additionally, the relevance of light-intensity physical activity (LIPA) in this context, which is an important contributor to total physical activity and may be a more feasible target for middle-to-older aged adults, remains unclear. Here, we examine the prospective associations of accelerometer-measured PA and ST with incident CVD (primary outcome), incident cancer, and all-cause mortality.
Humans, Neoplasms, Cardiovascular Diseases, Exercise, Mortality, Survival Analysis, Prospective Studies, Adult, Aged, Middle Aged, Female, Male, Accelerometry, Sedentary Behavior
The EPIC-Norfolk study (DOI 10.22025/2019.10.105.00004) has received funding from the Medical Research Council (MR/N003284/1 and MC-UU_12015/1) and Cancer Research UK (C864/A14136). PCD is supported by a National Health and Medical Research Council of Australia research fellowship (#1142685). PCD, TS, SB, KW and NJW are supported by the UK Medical Research Council [grant numbers MC_UU_12015/1 and MC_UU_12015/3].
Cambridge University Hospitals NHS Foundation Trust (CUH) (146281)
National Health and Medical Research Council (NHMRC) (via Baker Heart and Diabetes Institute) (APP 1142685)
Department of Health (via National Institute for Health Research (NIHR)) (NF-SI-0617-10149)
MEDICAL RESEARCH COUNCIL (MR/N003284/1)
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External DOI: https://doi.org/10.1161/circulationaha.119.043030
This record's URL: https://www.repository.cam.ac.uk/handle/1810/301863
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