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dc.contributor.authorHess, Christopheen
dc.date.accessioned2020-02-11T00:31:15Z
dc.date.available2020-02-11T00:31:15Z
dc.identifier.issn2211-1247
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/301954
dc.description.abstractThe innate immune system safeguards the organism from both pathogenic and environmental stressors. Also, physiologic levels of nutrients affect organismal and intra-cellular metabolism and challenge the immune system. In the long term, overnutrition leads to low-grade systemic inflammation. Here, we investigate tissue-resident components of the innate immune system –macrophages – and their response to short- and long-term nutritional challenges. We analyze the transcriptomes of six tissue-resident macrophage populations upon acute feeding and identify adipose tissue macrophages and the IL-1 pathway as early sensors of metabolic changes. Furthermore, by comparing functional responses between macrophage subtypes, we propose a regulatory, anti-inflammatory role of heat shock proteins of the HSP70 family in response to long- and short-term metabolic challenges. Our data provide a resource for assessing the impact of nutrition and over-nutrition on the spectrum of macrophages across tissues with a potential for identification of systemic responses.
dc.description.sponsorshipSwiss National Science Foundation
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleDistinct transcriptional responses across tissue-resident macrophages to short-term and long-term metabolic challengeen
dc.typeArticle
prism.publicationNameCell Reportsen
dc.identifier.doi10.17863/CAM.49031
dcterms.dateAccepted2019-12-31en
rioxxterms.versionofrecord10.1016/j.celrep.2020.01.005en
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-12-31en
dc.identifier.eissn2211-1247
rioxxterms.typeJournal Article/Reviewen
cam.issuedOnline2020-02-04en


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International