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dc.contributor.authorShah, Sonia
dc.contributor.authorHenry, Albert
dc.contributor.authorRoselli, Carolina
dc.contributor.authorLin, Honghuang
dc.contributor.authorSveinbjörnsson, Garðar
dc.contributor.authorFatemifar, Ghazaleh
dc.contributor.authorHedman, Åsa K
dc.contributor.authorWilk, Jemma B
dc.contributor.authorMorley, Michael P
dc.contributor.authorChaffin, Mark D
dc.contributor.authorHelgadottir, Anna
dc.contributor.authorVerweij, Niek
dc.contributor.authorDehghan, Abbas
dc.contributor.authorAlmgren, Peter
dc.contributor.authorAndersson, Charlotte
dc.contributor.authorAragam, Krishna G
dc.contributor.authorÄrnlöv, Johan
dc.contributor.authorBackman, Joshua D
dc.contributor.authorBiggs, Mary L
dc.contributor.authorBloom, Heather L
dc.contributor.authorBrandimarto, Jeffrey
dc.contributor.authorBrown, Michael R
dc.contributor.authorBuckbinder, Leonard
dc.contributor.authorCarey, David J
dc.contributor.authorChasman, Daniel I
dc.contributor.authorChen, Xing
dc.contributor.authorChen, Xu
dc.contributor.authorChung, Jonathan
dc.contributor.authorChutkow, William
dc.contributor.authorCook, James P
dc.contributor.authorDelgado, Graciela E
dc.contributor.authorDenaxas, Spiros
dc.contributor.authorDoney, Alexander S
dc.contributor.authorDörr, Marcus
dc.contributor.authorDudley, Samuel C
dc.contributor.authorDunn, Michael E
dc.contributor.authorEngström, Gunnar
dc.contributor.authorEsko, Tõnu
dc.contributor.authorFelix, Stephan B
dc.contributor.authorFinan, Chris
dc.contributor.authorFord, Ian
dc.contributor.authorGhanbari, Mohsen
dc.contributor.authorGhasemi, Sahar
dc.contributor.authorGiedraitis, Vilmantas
dc.contributor.authorGiulianini, Franco
dc.contributor.authorGottdiener, John S
dc.contributor.authorGross, Stefan
dc.contributor.authorGuðbjartsson, Daníel F
dc.contributor.authorGutmann, Rebecca
dc.contributor.authorHaggerty, Christopher M
dc.contributor.authorvan der Harst, Pim
dc.contributor.authorHyde, Craig L
dc.contributor.authorIngelsson, Erik
dc.contributor.authorJukema, J Wouter
dc.contributor.authorKavousi, Maryam
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorKleber, Marcus E
dc.contributor.authorKøber, Lars
dc.contributor.authorKoekemoer, Andrea
dc.contributor.authorLangenberg, Claudia
dc.contributor.authorLind, Lars
dc.contributor.authorLindgren, Cecilia M
dc.contributor.authorLondon, Barry
dc.contributor.authorLotta, Luca A
dc.contributor.authorLovering, Ruth C
dc.contributor.authorLuan, Jian'an
dc.contributor.authorMagnusson, Patrik
dc.contributor.authorMahajan, Anubha
dc.contributor.authorMargulies, Kenneth B
dc.contributor.authorMärz, Winfried
dc.contributor.authorMelander, Olle
dc.contributor.authorMordi, Ify R
dc.contributor.authorMorgan, Thomas
dc.contributor.authorMorris, Andrew D
dc.contributor.authorMorris, Andrew P
dc.contributor.authorMorrison, Alanna C
dc.contributor.authorNagle, Michael W
dc.contributor.authorNelson, Christopher P
dc.contributor.authorNiessner, Alexander
dc.contributor.authorNiiranen, Teemu
dc.contributor.authorO'Donoghue, Michelle L
dc.contributor.authorOwens, Anjali T
dc.contributor.authorPalmer, Colin N A
dc.contributor.authorParry, Helen M
dc.contributor.authorPerola, Markus
dc.contributor.authorPortilla-Fernandez, Eliana
dc.contributor.authorPsaty, Bruce M
dc.contributor.authorRice, Kenneth M
dc.contributor.authorRidker, Paul M
dc.contributor.authorRomaine, Simon P R
dc.contributor.authorRotter, Jerome I
dc.contributor.authorSalo, Perttu
dc.contributor.authorSalomaa, Veikko
dc.contributor.authorvan Setten, Jessica
dc.contributor.authorShalaby, Alaa A
dc.contributor.authorSmelser, Diane T
dc.contributor.authorSmith, Nicholas L
dc.contributor.authorStender, Steen
dc.contributor.authorStott, David J
dc.contributor.authorSvensson, Per
dc.contributor.authorTammesoo, Mari-Liis
dc.contributor.authorTaylor, Kent D
dc.contributor.authorTeder-Laving, Maris
dc.contributor.authorTeumer, Alexander
dc.contributor.authorThorgeirsson, Guðmundur
dc.contributor.authorThorsteinsdottir, Unnur
dc.contributor.authorTorp-Pedersen, Christian
dc.contributor.authorTrompet, Stella
dc.contributor.authorTyl, Benoit
dc.contributor.authorUitterlinden, Andre G
dc.contributor.authorVeluchamy, Abirami
dc.contributor.authorVölker, Uwe
dc.contributor.authorVoors, Adriaan A
dc.contributor.authorWang, Xiaosong
dc.contributor.authorWareham, Nicholas J
dc.contributor.authorWaterworth, Dawn
dc.contributor.authorWeeke, Peter E
dc.contributor.authorWeiss, Raul
dc.contributor.authorWiggins, Kerri L
dc.contributor.authorXing, Heming
dc.contributor.authorYerges-Armstrong, Laura M
dc.contributor.authorYu, Bing
dc.contributor.authorZannad, Faiez
dc.contributor.authorZhao, Jing Hua
dc.contributor.authorHemingway, Harry
dc.contributor.authorSamani, Nilesh J
dc.contributor.authorMcMurray, John J V
dc.contributor.authorYang, Jian
dc.contributor.authorVisscher, Peter M
dc.contributor.authorNewton-Cheh, Christopher
dc.contributor.authorMalarstig, Anders
dc.contributor.authorHolm, Hilma
dc.contributor.authorLubitz, Steven A
dc.contributor.authorSattar, Naveed
dc.contributor.authorHolmes, Michael V
dc.contributor.authorCappola, Thomas P
dc.contributor.authorAsselbergs, Folkert W
dc.contributor.authorHingorani, Aroon D
dc.contributor.authorKuchenbaecker, Karoline
dc.contributor.authorEllinor, Patrick T
dc.contributor.authorLang, Chim C
dc.contributor.authorStefansson, Kari
dc.contributor.authorSmith, J Gustav
dc.contributor.authorVasan, Ramachandran S
dc.contributor.authorSwerdlow, Daniel I
dc.contributor.authorLumbers, R Thomas
dc.date.accessioned2020-02-11T01:36:03Z
dc.date.available2020-02-11T01:36:03Z
dc.date.issued2020-01-09
dc.identifier.issn2041-1723
dc.identifier.otherPMC6952380
dc.identifier.other31919418
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/301956
dc.description.abstractHeart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report results from a GWAS meta-analysis of HF comprising 47,309 cases and 930,014 controls. Twelve independent variants at 11 genomic loci are associated with HF, all of which demonstrate one or more associations with coronary artery disease (CAD), atrial fibrillation, or reduced left ventricular function, suggesting shared genetic aetiology. Functional analysis of non-CAD-associated loci implicate genes involved in cardiac development (MYOZ1, SYNPO2L), protein homoeostasis (BAG3), and cellular senescence (CDKN1A). Mendelian randomisation analysis supports causal roles for several HF risk factors, and demonstrates CAD-independent effects for atrial fibrillation, body mass index, and hypertension. These findings extend our knowledge of the pathways underlying HF and may inform new therapeutic strategies.
dc.languageeng
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 2041-1723
dc.sourcenlmid: 101528555
dc.titleGenome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure.
dc.typeArticle
dc.date.updated2020-02-11T01:36:03Z
prism.issueIdentifier1
prism.publicationNameNature communications
prism.volume11
dc.identifier.doi10.17863/CAM.49033
rioxxterms.versionofrecord10.1038/s41467-019-13690-5
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidShah, Sonia [0000-0001-5860-4526]
dc.contributor.orcidHenry, Albert [0000-0001-7422-2288]
dc.contributor.orcidRoselli, Carolina [0000-0001-5267-6756]
dc.contributor.orcidLin, Honghuang [0000-0003-3043-3942]
dc.contributor.orcidChaffin, Mark D [0000-0002-1234-5562]
dc.contributor.orcidHelgadottir, Anna [0000-0002-1806-2467]
dc.contributor.orcidVerweij, Niek [0000-0002-4303-7685]
dc.contributor.orcidAlmgren, Peter [0000-0002-0473-0241]
dc.contributor.orcidChen, Xu [0000-0002-7299-3238]
dc.contributor.orcidGhanbari, Mohsen [0000-0002-9476-7143]
dc.contributor.orcidGiedraitis, Vilmantas [0000-0003-3423-2021]
dc.contributor.orcidGross, Stefan [0000-0003-4121-7161]
dc.contributor.orcidGuðbjartsson, Daníel F [0000-0002-5222-9857]
dc.contributor.orcidHyde, Craig L [0000-0002-6939-287X]
dc.contributor.orcidIngelsson, Erik [0000-0003-2256-6972]
dc.contributor.orcidJukema, J Wouter [0000-0002-3246-8359]
dc.contributor.orcidKleber, Marcus E [0000-0003-0663-7275]
dc.contributor.orcidKoekemoer, Andrea [0000-0001-8222-3547]
dc.contributor.orcidLangenberg, Claudia [0000-0002-5017-7344]
dc.contributor.orcidLindgren, Cecilia M [0000-0002-4903-9374]
dc.contributor.orcidLovering, Ruth C [0000-0002-9791-0064]
dc.contributor.orcidLuan, Jian'an [0000-0003-3137-6337]
dc.contributor.orcidMagnusson, Patrik [0000-0002-7315-7899]
dc.contributor.orcidMahajan, Anubha [0000-0001-5585-3420]
dc.contributor.orcidMordi, Ify R [0000-0002-2686-729X]
dc.contributor.orcidMorris, Andrew D [0000-0002-1766-0473]
dc.contributor.orcidNagle, Michael W [0000-0002-4677-7582]
dc.contributor.orcidNelson, Christopher P [0000-0001-8025-2897]
dc.contributor.orcidPalmer, Colin N A [0000-0002-6415-6560]
dc.contributor.orcidRice, Kenneth M [0000-0002-3071-7278]
dc.contributor.orcidRotter, Jerome I [0000-0001-7191-1723]
dc.contributor.orcidSalomaa, Veikko [0000-0001-7563-5324]
dc.contributor.orcidvan Setten, Jessica [0000-0002-4934-7510]
dc.contributor.orcidSvensson, Per [0000-0003-0372-6272]
dc.contributor.orcidTaylor, Kent D [0000-0002-2756-4370]
dc.contributor.orcidTeder-Laving, Maris [0000-0002-5872-1850]
dc.contributor.orcidTeumer, Alexander [0000-0002-8309-094X]
dc.contributor.orcidTyl, Benoit [0000-0001-5297-8412]
dc.contributor.orcidUitterlinden, Andre G [0000-0002-7276-3387]
dc.contributor.orcidVölker, Uwe [0000-0002-5689-3448]
dc.contributor.orcidWiggins, Kerri L [0000-0003-2749-1279]
dc.contributor.orcidHemingway, Harry [0000-0003-2279-0624]
dc.contributor.orcidYang, Jian [0000-0003-2001-2474]
dc.contributor.orcidVisscher, Peter M [0000-0002-2143-8760]
dc.contributor.orcidLubitz, Steven A [0000-0002-9599-4866]
dc.contributor.orcidSattar, Naveed [0000-0002-1604-2593]
dc.contributor.orcidCappola, Thomas P [0000-0002-9630-7204]
dc.contributor.orcidAsselbergs, Folkert W [0000-0002-1692-8669]
dc.contributor.orcidKuchenbaecker, Karoline [0000-0001-9726-603X]
dc.contributor.orcidEllinor, Patrick T [0000-0002-2067-0533]
dc.contributor.orcidVasan, Ramachandran S [0000-0001-7357-5970]
dc.contributor.orcidLumbers, R Thomas [0000-0002-9077-4741]
pubs.funder-project-idNovo Nordisk Fonden (NNF17OC0026936)


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International