Natural, modified DNA bases.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Bilyard, Matthew K
Becker, Sidney https://orcid.org/0000-0002-4746-2822
Balasubramanian, Shankar https://orcid.org/0000-0002-0281-5815
Abstract
The four canonical bases that make up genomic DNA are subject to a variety of chemical modifications in living systems. Recent years have witnessed the discovery of various new modified bases and of the enzymes responsible for their processing. Here, we review the range of DNA base modifications currently known and recent advances in chemical methodology that have driven progress in this field, in particular regarding their detection and sequencing. Elucidating the cellular functions of modifications remains an ongoing challenge; we discuss recent contributions to this area before exploring their relevance in medicine.
Description
Keywords
Detection, Epigenetic engineering, Functions of DNA modifications, Modified DNA bases, Modified base, Modified bases and disease, Sequencing, Animals, Base Pairing, Chromatography, Liquid, DNA, Epigenesis, Genetic, Humans, Mass Spectrometry, Sequence Analysis, DNA
Journal Title
Curr Opin Chem Biol
Conference Name
Journal ISSN
1367-5931
1879-0402
1879-0402
Volume Title
57
Publisher
Elsevier BV
Publisher DOI
Sponsorship
Wellcome Trust (209441/Z/17/Z)
Wellcome Trust (099232/Z/12/Z)
Cancer Research UK (18618)
Wellcome Trust (099232/Z/12/Z)
Cancer Research UK (18618)