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dc.contributor.authorLi, Jun
dc.contributor.authorGong, Hengfen
dc.contributor.authorXu, Hongmin
dc.contributor.authorDing, Qiong
dc.contributor.authorHe, Naying
dc.contributor.authorHuang, Ying
dc.contributor.authorJin, Ying
dc.contributor.authorZhang, Chencheng
dc.contributor.authorVoon, Valerie
dc.contributor.authorSun, Bomin
dc.contributor.authorYan, Fuhua
dc.contributor.authorZhan, Shikun
dc.date.accessioned2020-02-14T09:16:15Z
dc.date.available2020-02-14T09:16:15Z
dc.date.issued2020-01-31
dc.date.submitted2019-10-18
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/302183
dc.description.abstractObjectives: Late-life depression (LLD) has negative impacts on somatic, emotional and cognitive domains of the lives of patients. Elucidating the abnormality in the brain networks of LLD patients could help to strengthen the understanding of LLD pathophysiology, however, the studies exploring the spontaneous brain activity in LLD during the resting state remain limited. This study aimed at identifying the voxel-level whole-brain functional connectivity changes in LLD patients. Methods: Fifty patients with late-life depression (LLD) and 33 healthy controls were recruited. All participants underwent a resting-state functional magnetic resonance imaging scan to assess the voxel-wise degree centrality (DC) changes in the patients. Furthermore, DC was compared between two patient subgroups, the late-onset depression (LOD) and the early-onset depression (EOD). Results: Compared with the healthy controls, LLD patients showed increased DC in the inferior parietal lobule, parahippocampal gyrus, brainstem and cerebellum (p < 0.05, AlphaSim-corrected). LLD patients also showed decreased DC in the somatosensory and motor cortices and cerebellum (p < 0.05, AlphaSim-corrected). Compared with EOD patients, LOD patients showed increased centrality in the superior and middle temporal gyrus and decreased centrality in the occipital region (p < 0.05, AlphaSim-corrected). No significant correlation was found between the DC value and the symptom severity or disease duration in the patients after the correction for multiple comparisons. Conclusions: These findings indicate that the intrinsic abnormality of network centrality exists in a wide range of brain areas in LLD patients. LOD patients differ with EOD patients in cortical network centrality. Our study might help to strengthen the understanding of the pathophysiology of LLD and the potential neural substrates underlie related emotional and cognitive impairments observed in the patients.
dc.languageen
dc.publisherFrontiers Media S.A.
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectPsychiatry
dc.subjectlate-life depression
dc.subjectresting state
dc.subjectfunctional magnetic resonance imaging
dc.subjectdegree centrality
dc.subjectonset age
dc.titleAbnormal Voxel-Wise Degree Centrality in Patients With Late-Life Depression: A Resting-State Functional Magnetic Resonance Imaging Study
dc.typeArticle
dc.date.updated2020-02-14T09:16:14Z
prism.publicationNameFrontiers in Psychiatry
prism.volume10
dc.identifier.doi10.17863/CAM.49259
dcterms.dateAccepted2019-12-24
rioxxterms.versionofrecord10.3389/fpsyt.2019.01024
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.identifier.eissn1664-0640


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)