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dc.contributor.authorMenni, Cristinaen
dc.contributor.authorMcCallum, Linsayen
dc.contributor.authorPietzner, Maiken
dc.contributor.authorZierer, Jonasen
dc.contributor.authorAman, Alishaen
dc.contributor.authorSuhre, Karstenen
dc.contributor.authorMohney, Robert Pen
dc.contributor.authorMangino, Massimoen
dc.contributor.authorFriedrich, Neleen
dc.contributor.authorSpector, Tim Den
dc.contributor.authorPadmanabhan, Sandoshen
dc.date.accessioned2020-02-19T00:30:36Z
dc.date.available2020-02-19T00:30:36Z
dc.identifier.issn2045-2322
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/302369
dc.description.abstractElectrolytes have a crucial role in maintaining health and their serum levels are homeostatically maintained within a narrow range by multiple pathways involving the kidneys. Here we use metabolomics profiling (592 fasting serum metabolites) to identify molecular markers and pathways associated with serum electrolyte levels in two independent population-based cohorts. We included 1523 adults from TwinsUK not on blood pressure-lowering therapy and without renal impairment to look for metabolites associated with chloride, sodium, potassium and bicarbonate by running linear mixed models adjusting for covariates and multiple comparisons. For each electrolyte, we further performed pathway enrichment analysis (PAGE algorithm). Results were replicated in an independent cohort. Chloride, potassium, bicarbonate and sodium associated with 10, 58, 36 and 17 metabolites respectively (each P < 2.1 × 10-5), mainly lipids. Of all the electrolytes, serum potassium showed the most significant associations with individual fatty acid metabolites and specific enrichment of fatty acid pathways. In contrast, serum sodium and bicarbonate showed associations predominantly with amino-acid related species. In the first study to examine systematically associations between serum electrolytes and small circulating molecules, we identified novel metabolites and metabolic pathways associated with serum electrolyte levels. The role of these metabolic pathways on electrolyte homeostasis merits further studies.
dc.description.sponsorshipIncludes MRC, BHF, Wellcome Trust and NIHR.
dc.languageengen
dc.publisherNature Publishing Group
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleMetabolomic profiling identifies novel associations with Electrolyte and Acid-Base Homeostatic patterns.en
dc.typeArticle
prism.issueIdentifier1en
prism.number15088en
prism.publicationNameScientific Reportsen
prism.volume9en
dc.identifier.doi10.17863/CAM.49441
dcterms.dateAccepted2019-10-01en
rioxxterms.versionofrecord10.1038/s41598-019-51492-3en
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-10-01en
dc.identifier.eissn2045-2322
rioxxterms.typeJournal Article/Reviewen
cam.issuedOnline2019-10-21en


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International