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dc.contributor.authorWijeyekoon, Ruwani S
dc.contributor.authorMoore, Sarah F
dc.contributor.authorFarrell, Krista
dc.contributor.authorBreen, David P
dc.contributor.authorBarker, Roger A
dc.contributor.authorWilliams-Gray, Caroline H
dc.date.accessioned2020-02-20T00:30:40Z
dc.date.available2020-02-20T00:30:40Z
dc.date.issued2020-06
dc.identifier.issn0885-3185
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/302418
dc.description.abstractINTRODUCTION: Immune markers are altered in Parkinson's disease (PD), but relationships between cerebrospinal fluid (CSF) and plasma cytokines and associations with neurodegeneration-associated proteins remain unclear. METHODS: CSF and plasma samples and demographic/clinical measures were obtained from 35 PD patients. CSF samples were analyzed for cytokines (together with plasma) and for α-synuclein, amyloid β(1-42) peptide, total tau, and phospho(Thr231)-tau. RESULTS: There were no CSF-plasma cytokine correlations. Interleukin (IL)-8 was higher and interferon-γ, IL-10, and tumor necrosis factor-α were lower in CSF versus plasma. In CSF, total tau correlated positively with IL-8 and IL-1β, whereas α-synuclein correlated positively with amyloid β(1-42) and negatively with semantic fluency (a known marker of PD dementia risk). DISCUSSION: CSF and peripheral cytokine profiles in PD are not closely related. Associations between CSF IL-8 and IL-1β and tau suggest that CSF inflammatory changes may relate to tau pathology within PD. CSF α-synuclein/amyloid β may reflect the risk of developing PD dementia. © 2020 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
dc.description.sponsorshipFunding for this work was provided by the Rosetrees Trust (M369-F1), Addenbrooke’s Charitable Trust (PF15/CWG) and the NIHR Cambridge Biomedical Research Centre Dementia and Neurodegeneration Theme (146281). RSW was supported by a Fellowship from Addenbrooke’s Charitable Trust (RG77199). SFM was supported by the Transeuro EU FP7 grant (242003) and is now an NIHR Academic Clinical Fellow (ACF-2015-23-501). DPB is supported by a Wellcome Trust Clinical Research Career Development Fellowship. RAB is an NIHR Senior Investigator (NF-SI-0616-10011) and is supported by the Wellcome Trust-MRC Cambridge Stem Cell Institute. CHWG holds a RCUK/UKRI Research Innovation Fellowship awarded by the Medical Research Council (MR/R007446/1) and receives support from the Cambridge Centre for Parkinson-Plus.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherWiley
dc.rightsAll rights reserved
dc.subjectHumans
dc.subjectParkinson Disease
dc.subjectPeptide Fragments
dc.subjecttau Proteins
dc.subjectCytokines
dc.subjectalpha-Synuclein
dc.subjectAmyloid beta-Peptides
dc.subjectBiomarkers
dc.titleCerebrospinal Fluid Cytokines and Neurodegeneration-Associated Proteins in Parkinson's Disease.
dc.typeArticle
prism.endingPage1066
prism.issueIdentifier6
prism.publicationDate2020
prism.publicationNameMov Disord
prism.startingPage1062
prism.volume35
dc.identifier.doi10.17863/CAM.49489
dcterms.dateAccepted2020-02-13
rioxxterms.versionofrecord10.1002/mds.28015
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2020-06
dc.contributor.orcidBarker, Roger [0000-0001-8843-7730]
dc.contributor.orcidWilliams-Gray, Caroline [0000-0002-2648-9743]
dc.identifier.eissn1531-8257
rioxxterms.typeJournal Article/Review
pubs.funder-project-idAddenbrooke's Charitable Trust (ACT) (9968 MINUTE NO 24/14B)
pubs.funder-project-idAddenbrooke's Charitable Trust (ACT) (PF15/CWG)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (146281)
pubs.funder-project-idMedical Research Council (MR/R007446/1)
pubs.funder-project-idMedical Research Council (MC_PC_12009)
pubs.funder-project-idMedical Research Council (MC_PC_17230)
pubs.funder-project-idEuropean Commission (242003)
pubs.funder-project-idWellcome Trust (203151/Z/16/Z)
cam.issuedOnline2020-03-04
cam.orpheus.successTue Mar 31 10:35:51 BST 2020 - Embargo updated
rioxxterms.freetoread.startdate2023-02-19


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