Improved Acid Resistance of a Metal-Organic Cage Enables Cargo Release and Exchange between Hosts.
Angewandte Chemie (International ed. in English)
John Wiley & Sons Ltd.
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Xu, L., Zhang, D., Ronson, T., & Nitschke, J. (2020). Improved Acid Resistance of a Metal-Organic Cage Enables Cargo Release and Exchange between Hosts.. Angewandte Chemie (International ed. in English), 59 (19), 7435-7438. https://doi.org/10.1002/anie.202001059
Here we introduce the use of di(2-pyridyl)ketone in subcomponent self-assembly. When combined with a flexible triamine and zinc bis(trifluoromethylsulfon)imide, this ketone formed a new Zn4L4 tetrahedron 1 bearing twelve uncoordinated pyridyl units around its metal-ion vertices. The acid stability of 1 was found to be greater than that of the analogous tetrahedron 2 built from 2-formylpyridine. Intriguingly, the peripheral presence of additional pyridine rings in 1 resulted in distinct guest binding behavior from that of 2, affecting guest scope as well as binding affinities. The different stabilities and guest affinities of capsules 1 and 2 enabled the design of systems whereby different cargoes could be moved between cages using acid and base as chemical stimuli.
European Research Council (695009), UK Engineering and Physical Sciences Research Council (EPSRC EP/P027067/1)
European Commission Horizon 2020 (H2020) ERC (695009)
EPSRC (via University of Manchester) (EP/P027067/1)
External DOI: https://doi.org/10.1002/anie.202001059
This record's URL: https://www.repository.cam.ac.uk/handle/1810/302552
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