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Advances in cytomegalovirus (CMV) biology and its relationship to health, diseases, and aging.

Accepted version
Peer-reviewed

Type

Article

Change log

Authors

Nikolich-Žugich, Janko  ORCID logo  https://orcid.org/0000-0001-5830-5323
Čicin-Šain, Luka 
Collins-McMillen, Donna 
Jackson, Sarah 
Oxenius, Annette 

Abstract

Cytomegalovirus (CMV) is one of the largest and most ubiquitous latent persistent viruses. Most humans are infected with CMV early in life, and all immunocompetent humans spend several decades living with CMV. In the vast majority of the hosts, CMV does not cause manifest disease, and CMV therefore can be considered part of normal aging for 50-90% of the human population worldwide. Experimental, clinical, and epidemiological studies suggest that CMV carriage can have nuanced outcomes, including both potentially harmful and potentially beneficial impacts on the host. We here present a summary of the 7th International Workshop on CMV and Immunosenescence, covering various aspects of the interplay between CMV and its mammalian hosts in the context of virus spread, immune evasion, antiviral immunity, as well as the impact on health span and aging.

Description

Keywords

Aging, Cytomegalovirus, Immune evasion, Immunity, Latency, Aging, Animals, Cytomegalovirus, Cytomegalovirus Infections, Humans, Immunosenescence

Journal Title

Geroscience

Conference Name

Journal ISSN

2509-2715
2509-2723

Volume Title

42

Publisher

Springer Science and Business Media LLC

Rights

All rights reserved
Sponsorship
Medical Research Council (G0701279)
Medical Research Council (MR/K021087/1)
Medical Research Council (MR/S00081X/1)