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dc.contributor.authorMéndez-Ferrer, Simónen
dc.contributor.authorBonnet, Dominiqueen
dc.contributor.authorSteensma, David Pen
dc.contributor.authorHasserjian, Robert Pen
dc.contributor.authorGhobrial, Irene Men
dc.contributor.authorGribben, John Gen
dc.contributor.authorAndreeff, Michaelen
dc.contributor.authorKrause, Daniela Sen
dc.date.accessioned2020-03-06T00:30:50Z
dc.date.available2020-03-06T00:30:50Z
dc.date.issued2020-05en
dc.identifier.issn1474-175X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/303089
dc.description.abstractHaematological malignancies were previously thought to be driven solely by genetic or epigenetic lesions within haematopoietic cells. However, the niches that maintain and regulate daily production of blood and immune cells are now increasingly being recognized as having an important role in the pathogenesis and chemoresistance of haematological malignancies. Within haematopoietic cells, the accumulation of a small number of recurrent mutations initiates malignancy. Concomitantly, specific alterations of the niches, which support haematopoietic stem cells and their progeny, can act as predisposition events, facilitating mutant haematopoietic cell survival and expansion as well as contributing to malignancy progression and providing protection of malignant cells from chemotherapy, ultimately leading to relapse. In this Perspective, we summarize our current understanding of the composition and function of the specialized haematopoietic niches of the bone marrow during health and disease. We discuss disease mechanisms (rather than malignancy subtypes) to provide a comprehensive description of key niche-associated pathways that are shared across multiple haematological malignancies. These mechanisms include primary driver mutations in bone marrow niche cells, changes associated with increased hypoxia, angiogenesis and inflammation as well as metabolic reprogramming by stromal niche cells. Consequently, remodelling of bone marrow niches can facilitate immune evasion and activation of survival pathways favouring malignant haematopoietic cell maintenance, defence against excessive reactive oxygen species and protection from chemotherapy. Lastly, we suggest guidelines for the handling and biobanking of patient samples and analysis of the niche to ensure that basic research identifying therapeutic targets can be more efficiently translated to the clinic. The hope is that integrating knowledge of how bone marrow niches contribute to haematological disease predisposition, initiation, progression and response to therapy into future clinical practice will likely improve the treatment of these disorders.
dc.description.sponsorship. Original work discussed in this article was supported by core support grants from the Wellcome Trust and the MRC to the Cambridge Stem Cell Institute, National Health Service Blood and Transplant (United Kingdom), European Union’s Horizon 2020 research (ERC-2014-CoG-64765) and a Programme Foundation Award from Cancer Research UK to S.M.-F.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherSpringer Nature
dc.rightsAll rights reserved
dc.rights.uri
dc.subjectBone Marrow Cellsen
dc.subjectHematopoietic Stem Cellsen
dc.subjectAnimalsen
dc.subjectHumansen
dc.subjectHematologic Neoplasmsen
dc.subjectNeoplastic Stem Cellsen
dc.titleBone marrow niches in haematological malignancies.en
dc.typeArticle
prism.endingPage298
prism.issueIdentifier5en
prism.publicationDate2020en
prism.publicationNameNature reviews. Canceren
prism.startingPage285
prism.volume20en
dc.identifier.doi10.17863/CAM.50166
dcterms.dateAccepted2020-02-03en
rioxxterms.versionofrecord10.1038/s41568-020-0245-2en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2020-05en
dc.contributor.orcidMéndez-Ferrer, Simón [0000-0002-9805-9988]
dc.contributor.orcidBonnet, Dominique [0000-0002-4735-5226]
dc.contributor.orcidGhobrial, Irene M [0000-0001-7361-3092]
dc.contributor.orcidGribben, John G [0000-0002-8505-7430]
dc.contributor.orcidKrause, Daniela S [0000-0003-3603-1119]
dc.identifier.eissn1474-1768
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idECH2020 EUROPEAN RESEARCH COUNCIL (ERC) (648765)
pubs.funder-project-idNHS Blood and Transplant (NHSBT) ()
pubs.funder-project-idCancer Research UK (C61367/A26670)
pubs.funder-project-idCancer Research UK (A27831)
cam.orpheus.successTue Mar 31 10:35:24 BST 2020 - Embargo updated*
rioxxterms.freetoread.startdate2020-08-28


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