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dc.contributor.authorTan, Wei Keith
dc.contributor.authorRagunath, Krish
dc.contributor.authorWhite, Jonathan R
dc.contributor.authorSantiago, Jose
dc.contributor.authorFernandez-Sordo, Jacobo Ortiz
dc.contributor.authorPana, Mirela
dc.contributor.authorAlias, Bincy
dc.contributor.authorHadjinicolaou, Andreas V
dc.contributor.authorSujendran, Vijay
dc.contributor.authordi Pietro, Massimiliano
dc.date.accessioned2020-03-06T02:14:12Z
dc.date.available2020-03-06T02:14:12Z
dc.date.issued2020-01-22
dc.identifier.issn2364-3722
dc.identifier.otherPMC6976319
dc.identifier.other32010753
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/303093
dc.description.abstractBackground and study aims  The standard radiofrequency ablation (RFA) protocol for Barrett's esophagus (BE) encompasses an intermediary cleaning phase between two ablation sessions. A simplified protocol omitting the cleaning phase is less labor-intensive but equally effective in studies based on single ablation procedures. The aim of this study was to compare efficacy and safety of the standard and simplified RFA protocols for the whole treatment pathway for BE, including both circumferential and focal devices. Patients and methods  We performed a retrospective analysis of prospectively collected data on patients receiving RFA between January 2007 and August 2017 at two institutions. Outcomes assessed were: 1) complete remission of dysplasia (CR-D) and intestinal metaplasia (CR-IM) at 18 months; and 2) rate of esophageal strictures. Results  One hundred forty-five patients were included of whom 73 patients received the standard and 72 patients received the simplified protocol. CR-D was achieved in 94.5 % and 95.8 % of patients receiving the standard and simplified protocol, respectively ( P  = 0.71). CR-IM was achieved in 84.9 % and 77.8 % of patients treated with the standard and simplified protocol, respectively ( P  = 0.27). Strictures were significantly more common among patients who received the simplified protocol (12.5 %) compared to the standard protocol (1.4 %; P  = 0.008). The median number of esophageal dilations was one. Conclusion  The simplified RFA protocol is as effective as the standard protocol in eradicating BE but carries a higher risk of strictures. This needs to be taken into account, particularly in patients with higher pretreatment risk of strictures, such as those with esophageal narrowing from previous endoscopic mucosal resection (EMR).
dc.languageeng
dc.rightsEmbargo: ends 2020-02-01
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 2196-9736
dc.sourcenlmid: 101639919
dc.titleStandard versus simplified radiofrequency ablation protocol for Barrett's esophagus: comparative analysis of the whole treatment pathway.
dc.typeArticle
dc.date.updated2020-03-06T02:14:12Z
prism.endingPageE195
prism.issueIdentifier2
prism.publicationNameEndoscopy international open
prism.startingPageE189
prism.volume8
dc.identifier.doi10.17863/CAM.50170
rioxxterms.versionofrecord10.1055/a-1005-6331
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
pubs.funder-project-idDepartment of Health (ACF-2016-12-001)
rioxxterms.freetoread.startdate2020-02-01


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Embargo: ends 2020-02-01
Except where otherwise noted, this item's licence is described as Embargo: ends 2020-02-01