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Improved motion correction of submillimetre 7T fMRI time series with Boundary-Based Registration (BBR).

Published version
Peer-reviewed

Type

Article

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Authors

Huang, Pei 
Carlin, Johan D 
Henson, Richard N 
Correia, Marta M 

Abstract

Ultra-high field functional magnetic resonance imaging (fMRI) has allowed us to acquire images with submillimetre voxels. However, in order to interpret the data clearly, we need to accurately correct head motion and the resultant distortions. Here, we present a novel application of Boundary Based Registration (BBR) to realign functional Magnetic Resonance Imaging (fMRI) data and evaluate its effectiveness on a set of 7T submillimetre data, as well as millimetre 3T data for comparison. BBR utilizes the boundary information from high contrast present in structural data to drive registration of functional data to the structural data. In our application, we realign each functional volume individually to the structural data, effectively realigning them to each other. In addition, this realignment method removes the need for a secondary aligning of functional data to structural data for purposes such as laminar segmentation or registration to data from other scanners. We demonstrate that BBR realignment outperforms standard realignment methods across a variety of data analysis methods. For instance, the method results in a 15% increase in linear discriminant contrast, a cross-validated estimate of multivariate discriminability. Further analysis shows that this benefit is an inherent property of the BBR cost function and not due to the difference in target volume. Our results show that BBR realignment is able to accurately correct head motion in 7T data and can be utilized in preprocessing pipelines to improve the quality of 7T data.

Description

Keywords

Adult, Attention, Brain Mapping, Cerebral Cortex, Facial Recognition, Fixation, Ocular, Head Movements, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Pattern Recognition, Visual, Space Perception

Journal Title

Neuroimage

Conference Name

Journal ISSN

1053-8119
1095-9572

Volume Title

210

Publisher

Elsevier BV
Sponsorship
Medical Research Council (MC_UU_00005/14)
Medical Research Council (MC_UU_00005/8)