Repository logo
 

Feasibility of Quantitative Magnetic Resonance Fingerprinting in Ovarian Tumors for T1 and T2 Mapping in a PET/MR Setting.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Kaggie, Joshua D 
Deen, Surrin 
Kessler, Dimitri A 
Buonincontri, Guido  ORCID logo  https://orcid.org/0000-0002-8386-639X

Abstract

Multiparametric magnetic resonance imaging (MRI) can be used to characterize many cancer subtypes including ovarian cancer. Quantitative mapping of MRI relaxation values, such as T 1 and T 2 mapping, is promising for improving tumor assessment beyond conventional qualitative T 1- and T 2-weighted images. However, quantitative MRI relaxation mapping methods often involve long scan times due to sequentially measuring many parameters. Magnetic resonance fingerprinting (MRF) is a new method that enables fast quantitative MRI by exploiting the transient signals caused by the variation of pseudorandom sequence parameters. These transient signals are then matched to a simulated dictionary of T 1 and T 2 values to create quantitative maps. The ability of MRF to simultaneously measure multiple parameters, could represent a new approach to characterizing cancer and assessing treatment response. This feasibility study investigates MRF for simultaneous T 1, T 2, and relative proton density (rPD) mapping using ovarian cancer as a model system.

Description

Keywords

Ovarian cancer, Oncology, Magnetic resonance imaging (MRI), Imaging Techniques, Clinical Imaging, Cancer Applications

Journal Title

IEEE transactions on radiation and plasma medical sciences

Conference Name

Journal ISSN

2469-7311

Volume Title

3

Publisher

Sponsorship
Cancer Research UK (A16628, A16465)