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dc.contributor.authorCriswell, Katharine E
dc.contributor.authorGillis, J Andrew
dc.date.accessioned2020-03-27T01:51:39Z
dc.date.available2020-03-27T01:51:39Z
dc.date.issued2020-02-24
dc.identifier.issn2050-084X
dc.identifier.otherPMC7064331
dc.identifier.other32091389
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/303811
dc.description.abstractThe vertebral skeleton is a defining feature of vertebrate animals. However, the mode of vertebral segmentation varies considerably between major lineages. In tetrapods, adjacent somite halves recombine to form a single vertebra through the process of 'resegmentation'. In teleost fishes, there is considerable mixing between cells of the anterior and posterior somite halves, without clear resegmentation. To determine whether resegmentation is a tetrapod novelty, or an ancestral feature of jawed vertebrates, we tested the relationship between somites and vertebrae in a cartilaginous fish, the skate (Leucoraja erinacea). Using cell lineage tracing, we show that skate trunk vertebrae arise through tetrapod-like resegmentation, with anterior and posterior halves of each vertebra deriving from adjacent somites. We further show that tail vertebrae also arise through resegmentation, though with a duplication of the number of vertebrae per body segment. These findings resolve axial resegmentation as an ancestral feature of the jawed vertebrate body plan.
dc.languageeng
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 2050-084X
dc.sourcenlmid: 101579614
dc.subjectEvolution
dc.subjectSegmentation
dc.subjectdevelopmental biology
dc.subjectvertebrae
dc.subjectEvolutionary Biology
dc.subjectAxial Skeleton
dc.subjectChondrichthyan
dc.subjectSomites
dc.titleResegmentation is an ancestral feature of the gnathostome vertebral skeleton.
dc.typeArticle
dc.date.updated2020-03-27T01:51:38Z
prism.publicationNameeLife
prism.volume9
dc.identifier.doi10.17863/CAM.50891
rioxxterms.versionofrecord10.7554/eLife.51696
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidCriswell, Katharine E [0000-0002-4004-0192]
dc.contributor.orcidGillis, J Andrew [0000-0003-2062-3777]
pubs.funder-project-idRoyal Society (NF160762, UF130182)


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International