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dc.contributor.authorYuan, Shuai
dc.contributor.authorCarter, Paul
dc.contributor.authorVithayathil, Mathew
dc.contributor.authorKar, Siddhartha
dc.contributor.authorGiovannucci, Edward
dc.contributor.authorMason, Amy M
dc.contributor.authorBurgess, Stephen
dc.contributor.authorLarsson, Susanna C
dc.date.accessioned2020-03-28T01:59:26Z
dc.date.available2020-03-28T01:59:26Z
dc.date.issued2020-02-19
dc.identifier.issn2072-6643
dc.identifier.otherPMC7071358
dc.identifier.other32092884
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/303871
dc.description.abstractWe conducted a two-sample Mendelian randomization study to explore the associations of iron status with overall cancer and 22 site-specific cancers. Single-nucleotide polymorphisms for iron status were obtained from a genome-wide association study of 48,972 European-descent individuals. Summary-level data for breast and other cancers were obtained from the Breast Cancer Association Consortium and UK Biobank. Genetically predicted iron status was positively associated with liver cancer and inversely associated with brain cancer but not associated with overall cancer or the other 20 studied cancer sites at p < 0.05. The odds ratios of liver cancer were 2.45 (95% CI, 0.81, 7.45; p = 0.11), 2.11 (1.16, 3.83; p = 0.02), 10.89 (2.44, 48.59; p = 0.002) and 0.30 (0.17, 0.53; p = 2 × 10-5) for one standard deviation increment of serum iron, transferrin saturation, ferritin and transferrin levels, respectively. For brain cancer, the corresponding odds ratios were 0.69 (0.48, 1.00; p = 0.05), 0.75 (0.59, 0.97; p = 0.03), 0.41 (0.20, 0.88; p = 0.02) and 1.49 (1.04, 2.14; p = 0.03). Genetically high iron status was positively associated with liver cancer and inversely associated with brain cancer.
dc.languageeng
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 2072-6643
dc.sourcenlmid: 101521595
dc.subjectIron
dc.subjectFerritin
dc.subjectCancer
dc.subjectSerum transferrin
dc.subjectTransferrin Saturation
dc.subjectMendelian Randomization
dc.titleIron Status and Cancer Risk in UK Biobank: A Two-Sample Mendelian Randomization Study.
dc.typeArticle
dc.date.updated2020-03-28T01:59:25Z
prism.issueIdentifier2
prism.publicationNameNutrients
prism.volume12
dc.identifier.doi10.17863/CAM.50953
rioxxterms.versionofrecord10.3390/nu12020526
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidYuan, Shuai [0000-0001-5055-5627]
dc.contributor.orcidMason, Amy M [0000-0002-8019-0777]
pubs.funder-project-idVetenskapsrådet (2019-00977)
pubs.funder-project-idForskningsrådet om Hälsa, Arbetsliv och Välfärd (2018-00123)


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International