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dc.contributor.authorShu, Xiang
dc.contributor.authorLong, Jirong
dc.contributor.authorCai, Qiuyin
dc.contributor.authorKweon, Sun-Seog
dc.contributor.authorChoi, Ji-Yeob
dc.contributor.authorKubo, Michiaki
dc.contributor.authorPark, Sue K
dc.contributor.authorBolla, Manjeet K
dc.contributor.authorDennis, Joe
dc.contributor.authorWang, Qin
dc.contributor.authorYang, Yaohua
dc.contributor.authorShi, Jiajun
dc.contributor.authorGuo, Xingyi
dc.contributor.authorLi, Bingshan
dc.contributor.authorTao, Ran
dc.contributor.authorAronson, Kristan J
dc.contributor.authorChan, Kelvin Y K
dc.contributor.authorChan, Tsun L
dc.contributor.authorGao, Yu-Tang
dc.contributor.authorHartman, Mikael
dc.contributor.authorKee Ho, Weang
dc.contributor.authorIto, Hidemi
dc.contributor.authorIwasaki, Motoki
dc.contributor.authorIwata, Hiroji
dc.contributor.authorJohn, Esther M
dc.contributor.authorKasuga, Yoshio
dc.contributor.authorSoon Khoo, Ui
dc.contributor.authorKim, Mi-Kyung
dc.contributor.authorKong, Sun-Young
dc.contributor.authorKurian, Allison W
dc.contributor.authorKwong, Ava
dc.contributor.authorLee, Eun-Sook
dc.contributor.authorLi, Jingmei
dc.contributor.authorLophatananon, Artitaya
dc.contributor.authorLow, Siew-Kee
dc.contributor.authorMariapun, Shivaani
dc.contributor.authorMatsuda, Koichi
dc.contributor.authorMatsuo, Keitaro
dc.contributor.authorMuir, Kenneth
dc.contributor.authorNoh, Dong-Young
dc.contributor.authorPark, Boyoung
dc.contributor.authorPark, Min-Ho
dc.contributor.authorShen, Chen-Yang
dc.contributor.authorShin, Min-Ho
dc.contributor.authorSpinelli, John J
dc.contributor.authorTakahashi, Atsushi
dc.contributor.authorTseng, Chiuchen
dc.contributor.authorTsugane, Shoichiro
dc.contributor.authorWu, Anna H
dc.contributor.authorXiang, Yong-Bing
dc.contributor.authorYamaji, Taiki
dc.contributor.authorZheng, Ying
dc.contributor.authorMilne, Roger L
dc.contributor.authorDunning, Alison M
dc.contributor.authorPharoah, Paul D P
dc.contributor.authorGarcía-Closas, Montserrat
dc.contributor.authorTeo, Soo-Hwang
dc.contributor.authorShu, Xiao-Ou
dc.contributor.authorKang, Daehee
dc.contributor.authorEaston, Douglas F
dc.contributor.authorSimard, Jacques
dc.contributor.authorZheng, Wei
dc.date.accessioned2020-04-07T00:26:37Z
dc.date.available2020-04-07T00:26:37Z
dc.date.issued2020-03-05
dc.identifier.issn2041-1723
dc.identifier.otherPMC7057957
dc.identifier.other32139696
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/304160
dc.description.abstractKnown risk variants explain only a small proportion of breast cancer heritability, particularly in Asian women. To search for additional genetic susceptibility loci for breast cancer, here we perform a meta-analysis of data from genome-wide association studies (GWAS) conducted in Asians (24,206 cases and 24,775 controls) and European descendants (122,977 cases and 105,974 controls). We identified 31 potential novel loci with the lead variant showing an association with breast cancer risk at P < 5 × 10-8. The associations for 10 of these loci were replicated in an independent sample of 16,787 cases and 16,680 controls of Asian women (P < 0.05). In addition, we replicated the associations for 78 of the 166 known risk variants at P < 0.05 in Asians. These findings improve our understanding of breast cancer genetics and etiology and extend previous findings from studies of European descendants to Asian women.
dc.languageeng
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 2041-1723
dc.sourcenlmid: 101528555
dc.titleIdentification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants.
dc.typeArticle
dc.date.updated2020-04-07T00:26:37Z
prism.issueIdentifier1
prism.publicationNameNature communications
prism.volume11
dc.identifier.doi10.17863/CAM.51245
rioxxterms.versionofrecord10.1038/s41467-020-15046-w
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidPark, Sue K [0000-0001-5002-9707]
dc.contributor.orcidDennis, Joe [0000-0003-4591-1214]
dc.contributor.orcidYang, Yaohua [0000-0002-3815-7172]
dc.contributor.orcidShi, Jiajun [0000-0001-5194-0009]
dc.contributor.orcidLi, Bingshan [0000-0003-2129-168X]
dc.contributor.orcidIto, Hidemi [0000-0002-8023-4581]
dc.contributor.orcidKim, Mi-Kyung [0000-0001-5279-4162]
dc.contributor.orcidKong, Sun-Young [0000-0003-0620-4058]
dc.contributor.orcidLee, Eun-Sook [0000-0003-1122-8230]
dc.contributor.orcidLi, Jingmei [0000-0001-8587-7511]
dc.contributor.orcidLow, Siew-Kee [0000-0003-2386-0698]
dc.contributor.orcidMatsuda, Koichi [0000-0001-7292-2686]
dc.contributor.orcidMatsuo, Keitaro [0000-0003-1761-6314]
dc.contributor.orcidMuir, Kenneth [0000-0001-6429-988X]
dc.contributor.orcidPark, Min-Ho [0000-0003-1504-3815]
dc.contributor.orcidSpinelli, John J [0000-0002-9119-3287]
dc.contributor.orcidTsugane, Shoichiro [0000-0003-4105-2774]
dc.contributor.orcidMilne, Roger L [0000-0001-5764-7268]
dc.contributor.orcidDunning, Alison M [0000-0001-6651-7166]
dc.contributor.orcidPharoah, Paul D P [0000-0001-8494-732X]
dc.contributor.orcidGarcía-Closas, Montserrat [0000-0003-1033-2650]
dc.contributor.orcidTeo, Soo-Hwang [0000-0002-0444-590X]
dc.contributor.orcidEaston, Douglas F [0000-0003-2444-3247]
dc.contributor.orcidSimard, Jacques [0000-0001-6906-3390]
dc.contributor.orcidZheng, Wei [0000-0003-1226-070X]


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International