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dc.contributor.authorCohen-Berkman, Moran
dc.contributor.authorDudkevich, Reut
dc.contributor.authorBen-Hamo, Shani
dc.contributor.authorFishman, Alla
dc.contributor.authorSalzberg, Yehuda
dc.contributor.authorWaldman Ben-Asher, Hiba
dc.contributor.authorLamm, Ayelet T
dc.contributor.authorHenis-Korenblit, Sivan
dc.date.accessioned2020-04-07T01:07:59Z
dc.date.available2020-04-07T01:07:59Z
dc.date.issued2020-03-26
dc.date.submitted2019-08-06
dc.identifier.other50896
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/304168
dc.description.abstractHow lifespan and the rate of aging are set is a key problem in biology. Small RNAs are conserved molecules that impact diverse biological processes through the control of gene expression. However, in contrast to miRNAs, the role of endo-siRNAs in aging remains unexplored. Here, by combining deep sequencing and genomic and genetic approaches in Caenorhabditis elegans, we reveal an unprecedented role for endo-siRNA molecules in the maintenance of proteostasis and lifespan extension in germline-less animals. Furthermore, we identify an endo-siRNA-regulated tyrosine phosphatase, which limits the longevity of germline-less animals by restricting the activity of the heat shock transcription factor HSF-1. Altogether, our findings point to endo-siRNAs as a link between germline removal and the HSF-1 proteostasis and longevity-promoting somatic pathway. This establishes a role for endo siRNAs in the aging process and identifies downstream genes and physiological processes that are regulated by the endo siRNAs to affect longevity.
dc.languageen
dc.publishereLife Sciences Publications, Ltd
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectResearch Article
dc.subjectCell Biology
dc.subjectDevelopmental Biology
dc.subjectendogenous siRNAs
dc.subjectaging
dc.subjectproteostasis
dc.subjectHSF1
dc.subjectgermline
dc.subjectlongevity
dc.subjectC. elegans
dc.titleEndogenous siRNAs promote proteostasis and longevity in germline-less Caenorhabditis elegans
dc.typeArticle
dc.date.updated2020-04-07T01:07:59Z
prism.publicationNameeLife
prism.volume9
dc.identifier.doi10.17863/CAM.51253
dcterms.dateAccepted2020-03-26
rioxxterms.versionofrecord10.7554/elife.50896
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
datacite.contributor.supervisoreditor: Kaeberlein, Matt
datacite.contributor.supervisorsenior_editor: Ron, David
dc.contributor.orcidHenis-Korenblit, Sivan [0000-0001-8023-6336]
dc.identifier.eissn2050-084X
pubs.funder-project-idIsrael Science Foundation (689/19)
pubs.funder-project-idIsrael Science Foundation (927/18)
pubs.funder-project-idIsrael Ministry of Science, Technology and Sports (3-12066)
pubs.funder-project-idIsraeli Centers for Research Excellence (1796/12)


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)