EEG alpha reactivity and cholinergic system integrity in Lewy body dementia and Alzheimer's disease.
Thomas, Alan J
Peraza, Luis R
Donaghy, Paul C
Alzheimer's research & therapy
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Schumacher, J., Thomas, A. J., Peraza, L. R., Firbank, M., Cromarty, R., Hamilton, C. A., Donaghy, P. C., et al. (2020). EEG alpha reactivity and cholinergic system integrity in Lewy body dementia and Alzheimer's disease.. Alzheimer's research & therapy, 12 (1), 46. https://doi.org/10.1186/s13195-020-00613-6
Abstract Background: Lewy body dementia (LBD), which includes dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD), is characterized by marked deficits within the cholinergic system which are more severe than in Alzheimer’s disease (AD) and are mainly caused by degeneration of the nucleus basalis of Meynert (NBM) whose widespread cholinergic projections provide the main source of cortical cholinergic innervation. EEG alpha reactivity, which refers to the reduction in alpha power over occipital electrodes upon opening the eyes, has been suggested as a potential marker of cholinergic system integrity.
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External DOI: https://doi.org/10.1186/s13195-020-00613-6
This record's URL: https://www.repository.cam.ac.uk/handle/1810/304178
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