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dc.contributor.authorDimitri, Giovanna Maria
dc.contributor.authorBeqiri, Erta
dc.contributor.authorCzosnyka, Marek
dc.contributor.authorErcole, Ari
dc.contributor.authorSmielewski, Peter
dc.contributor.authorLio, Pietro
dc.contributor.authorCENTER-TBI High Resolution Substudy Participants and Investigators
dc.date.accessioned2020-04-17T23:30:29Z
dc.date.available2020-04-17T23:30:29Z
dc.date.issued2021
dc.identifier.issn0065-1419
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/304484
dc.description.abstractOBJECTIVE: In a previous study, we observed the presence of simultaneous increases in intracranial pressure (ICP) and the heart rate (HR), which we denominated cardio-cerebral crosstalk (CC), and we related the number of such events to patient outcomes in a paediatric cohort. In this chapter, we present an extension of this work to an adult cohort from the Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI) study. METHODS: We implemented a sliding window algorithm to detect CC events. We considered subwindows of 10-min observations. If simultaneous increases of at least 20% in ICP and HR occurred with respect to the minimum ICP and HR values in the time windows, a CC event was detected. Correlation between the number of CC events and mortality was then obtained. RESULTS: The cohort consisted of 226 adults (aged 16-85 years). The number of CC events that were detected varied (mean 50, standard deviation 58). A point biserial correlation coefficient of -0.13 between mortality and CC was found. Although the correlation was weaker than that seen in the paediatric cohort (-0.30), the negative direction was replicated. CONCLUSION: In this work, we first extracted CC events from ICP and HR observations of adult patients with traumatic brain injury and related the number of CC events to patient outcomes. Consistency with the previous results in the paediatric cohort was observed. The more crosstalk events occurred, the better the patient outcome was.
dc.format.mediumPrint
dc.languageeng
dc.publisherSpringer International Publishing
dc.rightsAll rights reserved
dc.subjectCENTER-TBI High Resolution Substudy Participants and Investigators
dc.subjectHumans
dc.subjectCohort Studies
dc.subjectHeart Rate
dc.subjectIntracranial Pressure
dc.subjectAlgorithms
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectMiddle Aged
dc.subjectChild
dc.subjectYoung Adult
dc.subjectBrain Injuries, Traumatic
dc.titleAnalysis of Cardio-Cerebral Crosstalk Events in an Adult Cohort from the CENTER-TBI Study.
dc.typeArticle
prism.endingPage42
prism.publicationDate2021
prism.publicationNameActa Neurochir Suppl
prism.startingPage39
prism.volume131
dc.identifier.doi10.17863/CAM.51563
dcterms.dateAccepted2020-04-14
rioxxterms.versionofrecord10.1007/978-3-030-59436-7_9
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021-01
dc.contributor.orcidErcole, Ari [0000-0001-8350-8093]
dc.contributor.orcidSmielewski, Peter [0000-0001-5096-3938]
dc.contributor.orcidLio, Pietro [0000-0002-0540-5053]
dc.identifier.eissn2197-8395
rioxxterms.typeJournal Article/Review
pubs.funder-project-idEuropean Commission (602150)
cam.issuedOnline2021-04-11
cam.orpheus.successMon May 31 07:36:32 BST 2021 - Embargo updated
cam.orpheus.counter62
rioxxterms.freetoread.startdate2022-01-31


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