Lysophosphatidic Acid and Hematopoiesis: From Microenvironmental Effects to Intracellular Signaling.
International journal of molecular sciences
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Lin, K., Chiang, J., Ho, Y., Yao, C., & Lee, H. (2020). Lysophosphatidic Acid and Hematopoiesis: From Microenvironmental Effects to Intracellular Signaling.. International journal of molecular sciences, 21 (6)https://doi.org/10.3390/ijms21062015
Vertebrate hematopoiesis is a complex physiological process that is tightly regulated by intracellular signaling and extracellular microenvironment. In recent decades, breakthroughs in lineage-tracing technologies and lipidomics have revealed the existence of numerous lipid molecules in hematopoietic microenvironment. Lysophosphatidic acid (LPA), a bioactive phospholipid molecule, is one of the identified lipids that participates in hematopoiesis. LPA exhibits various physiological functions through activation of G-protein-coupled receptors. The functions of these LPARs have been widely studied in stem cells, while the roles of LPARs in hematopoietic stem cells have rarely been examined. Nonetheless, mounting evidence supports the importance of the LPA-LPAR axis in hematopoiesis. In this article, we have reviewed regulation of hematopoiesis in general and focused on the microenvironmental and intracellular effects of the LPA in hematopoiesis. Discoveries in these areas may be beneficial to our understanding of blood-related disorders, especially in the context of prevention and therapy for anemia.
Anemia, Lysophosphatidic acid, Hematopoiesis, Microenvironment, Lysophosphatidic Acid Receptors, Transcription Factor Networks
Ministry of Science and Technology, Taiwan (108-2314-B-002 -115 -MY2)
External DOI: https://doi.org/10.3390/ijms21062015
This record's URL: https://www.repository.cam.ac.uk/handle/1810/304529
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/