Impact of Chronic Fetal Hypoxia and Inflammation on Cardiac Pacemaker Cell Development.
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Frasch, Martin G https://orcid.org/0000-0003-3159-6321
Giussani, Dino A https://orcid.org/0000-0002-1308-1204
Abstract
Chronic fetal hypoxia and infection are examples of adverse conditions during complicated pregnancy, which impact cardiac myogenesis and increase the lifetime risk of heart disease. However, the effects that chronic hypoxic or inflammatory environments exert on cardiac pacemaker cells are poorly understood. Here, we review the current evidence and novel avenues of bench-to-bed research in this field of perinatal cardiogenesis as well as its translational significance for early detection of future risk for cardiovascular disease.
Description
Keywords
Cardiac development, Sinus Node, Fetal Programming, Ihrv, Intrinsic Heart Rate Variability
Journal Title
Cells
Conference Name
Journal ISSN
2073-4409
Volume Title
9