Impact of Chronic Fetal Hypoxia and Inflammation on Cardiac Pacemaker Cell Development.
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Frasch, M. G., & Giussani, D. A. (2020). Impact of Chronic Fetal Hypoxia and Inflammation on Cardiac Pacemaker Cell Development.. Cells, 9 (3)https://doi.org/10.3390/cells9030733
Chronic fetal hypoxia and infection are examples of adverse conditions during complicated pregnancy, which impact cardiac myogenesis and increase the lifetime risk of heart disease. However, the effects that chronic hypoxic or inflammatory environments exert on cardiac pacemaker cells are poorly understood. Here, we review the current evidence and novel avenues of bench-to-bed research in this field of perinatal cardiogenesis as well as its translational significance for early detection of future risk for cardiovascular disease.
Cardiac development, Sinus Node, Fetal Programming, Ihrv, Intrinsic Heart Rate Variability
External DOI: https://doi.org/10.3390/cells9030733
This record's URL: https://www.repository.cam.ac.uk/handle/1810/304566
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/