Placental imprinting: Emerging mechanisms and functions
Published version
Peer-reviewed
Repository URI
Repository DOI
Type
Article
Change log
Authors
Hanna, Courtney W. https://orcid.org/0000-0002-4063-5575
Abstract
As the maternal–foetal interface, the placenta is essential for the establishment and progression of healthy pregnancy, regulating both foetal growth and maternal adaptation to pregnancy. The evolution and functional importance of genomic imprinting are inextricably linked to mammalian placentation. Recent technological advances in mapping and manipulating the epigenome in embryogenesis in mouse models have revealed novel mechanisms regulating genomic imprinting in placental trophoblast, the physiological implications of which are only just beginning to be explored. This review will highlight important recent discoveries and exciting new directions in the study of placental imprinting.
Description
Keywords
Review, Biology and life sciences, Research and analysis methods
Journal Title
PLOS Genetics
Conference Name
Journal ISSN
1553-7390
1553-7404
1553-7404
Volume Title
16
Publisher
Public Library of Science